Medications Affecting Clozapine Level?
Clozapine is indicated for the management of treatment resistant schizophrenia and hence it is likely that patient will also be taking other psychotropic and non-psychotropic…
Clozapine is indicated for the management of treatment resistant schizophrenia and hence it is likely that patient will also be taking other psychotropic and non-psychotropic…
STEROIDS & NEUROPSYCHIATRIC ADVERSE EVENTS Neuropsychiatric Adverse Events from Non-Psychiatric Medications Patients on higher doses of steroids can present with affective, behavioral, and cognitive symptoms.…
Can Ginkgo Biloba help with antidepressant-induced sexual dysfunction? WHAT IS THE LIKELY MECHANISM OF ACTION: Prostaglandin synthesis and vasodilation ==> resulting in increase peripheral blood…
Traumatic brain injury can significantly impact an individual’s life, in terms of cognitive, behavioral, and physical impairments. Among these, aggression remains the most challenging for…
Recently Omega-3 polyunsaturated fatty acids, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) have drawn the clinical attention for the treatment of major depressive disorder. The…
Psychiatry Education Forum Academy just finished the lecture series on Understanding Lithium’s Adverse Events Management. Here we have discussed the clinical details of how to…
We continue our lecture series on Lithium Adverse Events Management with the discussion of Lithium Induced Gastrointestinal side effects. Nausea and/or diarrhea are common gastrointestinal…
We continue our lecture series on Lithium Adverse Events Management with the discussion of Lithium Induced Hyperparathyroidism. The first case of Lithium induced hyperparathyroidism was…
We continue our lecture series on Lithium Adverse Events Management with the discussion of Lithium Induced Hypothyroidism. The antithyroid effects of lithium were recognized in…
We continue our lecture series on Lithium Adverse Events Management with the discussion of Lithium Induced Tremors. Tremors are one of the common side effects…
Lithium is the oldest mood stabilizer approved for bipolar disorder and still is considered the gold standard treatment. Lithium is not protein bound, is not…
Viloxazine ER (Qelbree) was initially approved for pediatric ADHD and now had received FDA approval for the management of ADHD in adult patients. We have…
A patient in his mid 30s was brought to the hospital by police for increased aggression towards his family members. On evaluation he reported a…
Lumateperone received its first FDA approval for the management of adult schizophrenia in 2019, and recently FDA has just approved this medication for depressive episodes…
Gabapentin is currently FDA approved for restless leg syndrome, partial-onset seizures, and postherpetic neuralgia. Although not a first-line medication, recently many studies have shown gabapentin…
This post will summarize Trazodone’s mechanism of action and answer the following two questions: What dose of Trazodone is effective for major depression disorder (MDD)…
Today FDA has approved the first sublingual medication, IGALMI (Dexmedetomidine) for the management of acute agitation in indications discussed below. We have summarized this medication…
Valproate is considered the first-line medication for bipolar disorder management but is known to cause various adverse events. Among these adverse events, tremors are one…
On March 14, 2022: FDA has approved the first and only once-weekly transdermal patch for Alzheimer’s dementia: Adlarity (Donepezil). Psychiatry Education Forum Academy has summarized…
Psychiatry Education Forum Academy (PEFA) is excited to announce our next lecture series on “Impulse Control & Self Injurious Behaviors: Pharmacological Management”. Today we released…
Cannabis is one of the commonly used illicit substances. The use has increased further with multiple states legalizing cannabis use in the United States. Cannabis…
Antidepressant-induced excessive sweating (ADIES) is reported in more than 20% of patients taking antidepressants. For this reason, the knowledge on how to identify and manage…
BEFORE SCROLLING DOWN ==> SUBMIT YOUR ANSWERS FIRST 🙂 Antidepressant treatment is indicated for post-partum depression. For this reason, it is of direct clinical relevance…
According to the International Classification of Sleep Disorders (Third Edition), Insomnia is defined as: either trouble initiating or maintaining sleep, associated with daytime consequences, and…
Although benzodiazepines are only indicated for short-term prescription use, a certain percentage of patients can end up on the long-term use resulting in both physiological…
Share This Post Share on facebook Share on linkedin Share on twitter Share on email Close to 70-90 % of reproductive age women are known…
On Jan 10, 2022, FDA has approved this new medication for treatment of adults with insomnia: Quviviq (daridorexant). This FDA approval is based on the…
Depression in bipolar disorder is considered the most common mood phase and also a major clinical challenge. This is known to cause impairment from being…
Dec 20, 2021. We know that Lumateperone received its first FDA approval for the management of adult schizophrenia in 2019, but FDA has just approved…
Today, we released the journal club #13 for our psychiatry education forum academy members. This journal club will compare the findings of this 2014 study…
Serotonin modulators are a class of medications approved for the treatment of the major depressive disorder. Psychiatry Education Forum Academy’s recent chapter will compare these…
BEFORE SCROLLING DOWN ==> SUBMIT YOUR ANSWERS FIRST 🙂 According to this review article published in BMC Gastroenterology: Level 1 Evidence is based on ≥…
BEFORE SCROLLING DOWN ==> SUBMIT YOUR ANSWERS FIRST 🙂 There is growing evidence that patients with comorbid obsessive-compulsive disorder (OCD) and schizophrenia may represent a…
Can Ginkgo Biloba help with antidepressants induced sexual dysfunction? MECHANISM OF ACTION: Prostaglandin synthesis and vasodilation ==> resulting in increase peripheral blood flow and to…
Lithium is considered the gold standard and first-line treatment for bipolar disorder and is known to have adverse effects on the kidney, thyroid, parathyroid, neurological…
Attention-deficit/hyperactivity disorder (ADHD) is a common and impairing disorder affecting children, adolescents, and adults. Stimulant class of medications are considered first-line treatment for ADHD, including…
A 43-year-old male with a history of major depressive disorder is referred to you by his primary care physician for management of depression with the…
ADHD is a common neurobehavioral disorder that can persist into adulthood and treatment can have a significant positive impact on a person’s daily functioning. ADHD…
With the IR formulation, the rate is 0.4% (4/1000) at doses of 300 to 450 mg/day. With the SR formulation, the rate is 0.1% (1/1000)…
SNRIs: Venlafaxine vs Duloxetine © Psychiatry Education Forum FOR ACADEMY MEMBERS: (1) SNRI use with RENAL impairment This chapter will summarize the dosage adjustment of…
L-MethylFolate is used as an augmentation agent to antidepressants in patients with major depression disorder, but who is a good candidate for considering L-Methylfolate as…
The drug interaction between Lamotrigine and Oral Contraceptives is of direct clinical relevance for your daily clinical practice. This topic is summarized in the following…
Clozapine is considered a gold-standard medication for treatment-resistant schizophrenia, but close to 50% of these patients on clozapine may show poor or no response. What…
Generalized Anxiety Disorder (GAD) is a common psychiatric disorder with chronic waxing and waning course for some. Serotonergic medications (SSRIs and SNRIs) are considered first-line…
Valproate is considered first-line treatment for the management of bipolar disorder with the following recommendations per recent CANMAT & ISBD 2018 guidelines: Acute Mania: First…
Partial response, no response, or residual symptoms following antidepressant therapy is common in clinical psychiatry. Hence, it is of clinical importance to have knowledge of…
Answer: (b) Sertraline. Warfarin has two isomers: S-isomer (three times more potent than R-isomer): metabolized by 2C9. R-isomer: metabolized by 1A2 (major) and 2C19 & 3A4 (minor) —> monitor…
Pramipexole is currently only FDA approved for Parkinson’s disease & Moderate-to-severe primary Restless Legs Syndrome but Pramipexole has promising data as an augmentation option for…
Antidepressants are well known to cause this side effects of emotional blunting. It is clinically relevant to diagnose this early in the treatment as this…
Sep 01, 2021. Today FDA approved the first and only 6 monthly long-acting injectable for schizophrenia treatment: Invega Hafyera. We have summarized Invega Hafyera clinical…
Topiramate is well known to cause cognitive dulling and patients should use caution when operating machinery including automobiles. How can we prevent the risk of…
Depression with atypical features is defined as significant mood reactivity combined with two of the following clinical features: Hyperphagia Hypersomnia Leaden paralysis Pathological rejection sensitivity…
The perinatal period can increase the risk of mood symptoms recurrence for patients with bipolar disorder, including the risk of depressive episode recurrences and postpartum…
Depression and anxiety are common comorbidities in breast cancer patients. As a results patients with breast cancer may require treatment with antidepressants. For this reason,…
We know that dopamine agonism can result in hypersexual or paraphilic behaviors but interestingly, case reports for second-generation antipsychotics association with increase in hypersexual behavior…
We know that CBT and SSRI are considered first-line treatments for pediatric OCD management, but few patients are treatment-refractory and they do not respond to…
The diagnosis of PTSD requires the endorsement of one of two symptoms from the symptom clusters of (1) reexperiencing, (2) avoidance, and (3) sense of…
OCD is a chronic neuropsychiatric disorder that can cause significant psychosocial impairment (Goodman et al., 2021), and delay in treatment is associated with poor outcomes…
Therapeutic Drug Monitoring (TDM) of psychotropic medication is a clinically relevant topic as TDM can be a beneficial test in following clinical scenarios checking medication…
Antipsychotic-induced edema is not an uncommon side-effect. In most cases, this can be a transient and self-limited side effect but it is important to know…
We know that medications are not the first-line treatment for autism spectrum disorder (ASD) management but they are helpful when first-line behavioral interventions are not…
Alzheimer’s disease is the most common type/cause of dementia. As we know that FDA recently approved Aducanumab (Aduhelm) for the treatment of Alzheimer’s Disease (read…
Today we posted the following 11th journal club in PEFA Journal Club’s discussion series and discussion with an expert in our Coffee Club’s discussion section:…
Today we posted our 10th journal club in PEFA Journal Club’s discussion series, discussing the risk of weight gain with antipsychotics: Journal Club #10: Almost…
Today we posted the following 9th journal club in PEFA Journal Club’s discussion series and discussion with an expert in our Coffee Club’s discussion section:…
Today we posted the eighth journal club in PEFA Journal Club’s discussion series, discussing if Vortioxetine is effective for emotional blunting in MDD after inadequate…
Valproate is an FDA approved treatment for bipolar disorder. According to CANMAT and ISBD (2018 guidelines) valproate is indicated for the following phases of bipolar…
Glycopyrrolate is preferred over Benztropine for the following reasons: for Glycopyrrolate is less known to cross the blood-brain barrier, hence less central adverse events (less…
Tinnitus is defined as the conscious awareness of a sound in the absence of an external auditory stimulus. Psychotropic medications are commonly used as the…
Naltrexone XR is an opioid antagonist, which is FDA approved for opioid use disorder. The main benefits of naltrexone-XR are: extended duration of its action…
ANSWER: (d) All of the above. Apply to a different application site each time a new transdermal system is applied. Do not cut the patch.…
Restless leg syndrome is defined as having following four essential clinical consensus criteria: (a) Compelling urge to move the legs with or caused by uncomfortable…
Share this post Share on facebook Share on google Share on twitter Share on linkedin Share on pinterest Share on print Share on email Bipolar…
PROPRANOLOL FOR TRAUMATIC BRAIN INJURY Traumatic brain injury can significantly impact an individual’s life, in terms of cognitive, behavioral, and physical impairments. Among these, aggression…
ASENAPINE: TRANSDERMAL VS SUBLINGUAL This post will summarize the key differences between the transdermal and sublingual formulation of asenapine in the following 10 minutes of…
How to Minimize Renal Damage Risk with Chronic Lithium Use? <img width=”768″ height=”854″ src=”https://psychiatryeducationforum.com/project1/wp-content/uploads/2020/11/02889320-0192-4269-938a-0f27a483c3f2-copy-768×854.jpg” alt=”” loading=”lazy” srcset=”https://i1.wp.com/www.psychiatryeducationforum.com/wp-content/uploads/2020/11/02889320-0192-4269-938a-0f27a483c3f2-copy.jpg?resize=768%2C854&ssl=1 768w, https://i1.wp.com/www.psychiatryeducationforum.com/wp-content/uploads/2020/11/02889320-0192-4269-938a-0f27a483c3f2-copy.jpg?resize=270%2C300&ssl=1 270w, https://i1.wp.com/www.psychiatryeducationforum.com/wp-content/uploads/2020/11/02889320-0192-4269-938a-0f27a483c3f2-copy.jpg?w=813&ssl=1 813w” sizes=”(max-width: 768px) 100vw,…
ROLE OF NAC FOR TREATMENT-RESISTANT OCD This is a short 5-minute video from <a href=”https://psychiatryeducationforum.teachable.com/p/conference1″ target=”_blank” rel=”noopener noreferrer”>Psychiatry Education Forum’s 1st CME Conference</a>. Here I…
MONTELUKAST & NEUROPSYCHIATRIC ADVERSE EVENTS Neuropsychiatric Adverse Events from Non-Psychiatric Medications BY DR. HARVINDER SINGH Montelukast is indicated for the treatment of: Prophylaxis and chronic…
This post will compare trazodone and nefazodone in the following table: INTERESTED IN LEARNING MORE? JOIN OUR ACADEMY & GET ACCESS TO FOLLOWING COMPLETE LECTURE…
On Oct 22, 2020: FDA approved the antiviral medication Remdesivir for the treatment of COVID-19 requiring hospitalization. This was the first treatment for COVID-19 to…
This video podcast will be discussed in the following sections: 1. Available lithium formulations and dosages.2. Lithium Citrate vs Lithium Carbonate.3. Which lithium formulation &…
On Oct 9, 2020: Alkermes announced that FDA Advisory Committee voted in support of ALKS 3831 for the treatment of schizophrenia and bipolar I disorder.…
Bruxism is an involuntary activity of the jaw musculature characterized by jaw clenching, bracing, gnashing, and grinding of the teeth. Antidepressants induced bruxism is an…
Lithium is considered a gold-standard mood stabilizer for the management of bipolar disorder. How about managing bipolar disorder with lithium during pregnancy OR for a…
Prazosin is used for treatment of intrusive nightmares and flashbacks symptoms of PTSD. Prazosin has limitation in some patients due to: Need for multiple dosings…
This post will focus on the following three available long-acting formulations of antidepressants: (1) FLUOXETINE CR: Comparing daily fluoxetine with weekly fluoxetine in terms of:…
This question is more directed toward drug-drug interactions and the role of Cytochrome P450: Atomoxetine is metabolized by CYP2D6, so we should avoid medications inhibiting…
Neutropenia is the single most important risk factor for infection and Clozapine is well known for the increased for neutropenia. This neutropenia risk will increase…
On Oct 15, 2019 FDA has approved the first-and-only transdermal patch for the treatment of adults with schizophrenia: SECUADO® (asenapine) Transdermal Patch This post will…
Let’s begin this discussion with the following hypothetical case: <img width=”640″ height=”360″ src=”https://psychiatryeducationforum.com/project1/wp-content/uploads/2020/08/Pink-Blooming-Bridal-Bouquets-Sales-Presentation-2-1024×576.png” alt=”” srcset=”https://i0.wp.com/www.psychiatryeducationforum.com/wp-content/uploads/2020/08/Pink-Blooming-Bridal-Bouquets-Sales-Presentation-2.png?resize=1024%2C576&ssl=1 1024w, https://i0.wp.com/www.psychiatryeducationforum.com/wp-content/uploads/2020/08/Pink-Blooming-Bridal-Bouquets-Sales-Presentation-2.png?resize=300%2C169&ssl=1 300w, https://i0.wp.com/www.psychiatryeducationforum.com/wp-content/uploads/2020/08/Pink-Blooming-Bridal-Bouquets-Sales-Presentation-2.png?resize=768%2C432&ssl=1 768w, https://i0.wp.com/www.psychiatryeducationforum.com/wp-content/uploads/2020/08/Pink-Blooming-Bridal-Bouquets-Sales-Presentation-2.png?resize=1536%2C864&ssl=1 1536w, https://i0.wp.com/www.psychiatryeducationforum.com/wp-content/uploads/2020/08/Pink-Blooming-Bridal-Bouquets-Sales-Presentation-2.png?w=1920&ssl=1 1920w, https://i0.wp.com/www.psychiatryeducationforum.com/wp-content/uploads/2020/08/Pink-Blooming-Bridal-Bouquets-Sales-Presentation-2.png?w=1280&ssl=1…
This short 10 min video will discuss the important drug interactions for commonly used mood stabilizers for bipolar disorder management: Our course chapter will compare…
Stimulants have been intuitively considered as treatment options for depression for a very long time. It is often said that Freud treated his own depression…
We all know about the risk of extrapyramidal symptoms with the use of antipsychotics. A similar risk can also be seen with antidepressants, but this…
Agitation is seen in various psychiatric disorders including bipolar disorder and schizophrenia. The use of intramuscular and intravenous medications is common in hospital settings for…
Do you know of a condition “which causes such suffering that it should be known by every physician”?(1) That is what Ekbom, the neurologist who…
Clozapine as a treatment option has many strengths. But it also has some weaknesses. This week I had a patient who has been stable on…
The Psychopharmacology Algorithm Project at the Harvard South Shore Program published algorithms for bipolar depression in 1999 and 2010. They just released their updated guidelines…
For Physician’s Guide for Clinical Psychiatry Subscribers: Read this chapter for details: (2.34) OTHERS: Hydroxyzine and QTc Prolongation. Read Course Chapter Dr. Harvinder Singh Admin,…
For Physician’s Guide for Clinical Psychiatry Course Subscribers: (This chapter is only available to course subscribers) This topic will be discussed in the following sections:…
Dasotraline is an investigational medication discovered by Sunovion Pharmaceuticals Inc. and is currently under development for the treatment of: ADHD (in children) and Binge eating…
Lithium induced neuropathy is a rare side effect of lithium. We will discuss this adverse event in the following sections: Underlying mechanism. Clinical Presentation: onset,…
Detailed answer is available in our first email of Psychotropics Drug-Drug Interactions lecture series:- <a data-elementor-open-lightbox=”” href=”https://app.getresponse.com/view/a62b/EwvVVzw/whArc/email-message/bhdkY” target=”_blank” rel=”noopener noreferrer”> <img width=”599″ height=”638″ src=”https://psychiatryeducationforum.com/project1/wp-content/uploads/2020/01/Screen-Shot-2020-01-08-at-1.20.08-PM.png” alt=””…
Detailed answer is available in our next email in the lecture series: <h3><a href=”https://app.getresponse.com/view/a62b/EFlZJSI/whArc/broadcast/18Akc” target=”_blank” rel=”noopener noreferrer”>Antidepressants use with Cardiac Risk</a></h3> <img width=”980″ height=”735″ src=”https://psychiatryeducationforum.com/project1/wp-content/uploads/2019/12/Antidepressants-Cardiac.001.jpeg”…
Switching Antidepressants Versus Adding Augmentation Agent in MDD. <h3>How do you decide?</h3> <h4>This question is answered by following two studies:</h4> <h3>(1) Canadian Network for Mood…
WATCH THIS VIDEO FOR MORE DETAILS: This video will compare Lithium, Depakote, Carbamazepine, Oxcarbazepine and Lamotrigine in following sections: FDA Indications. CANMAT and ISBD 2018…
Choose your answer before scrolling down. Lamotrigine is metabolized predominantly by glucuronic acid conjugation, so medications that induce or inhibit glucuronidation may affect…
Answer: <img width=”1024″ height=”729″ src=”https://psychiatryeducationforum.com/project1/wp-content/uploads/2019/10/Screen-Shot-2019-10-29-at-3.32.28-PM-1024×729.png” alt=”” srcset=”https://i0.wp.com/www.psychiatryeducationforum.com/wp-content/uploads/2019/10/Screen-Shot-2019-10-29-at-3.32.28-PM.png?resize=1024%2C729&ssl=1 1024w, https://i0.wp.com/www.psychiatryeducationforum.com/wp-content/uploads/2019/10/Screen-Shot-2019-10-29-at-3.32.28-PM.png?resize=300%2C213&ssl=1 300w, https://i0.wp.com/www.psychiatryeducationforum.com/wp-content/uploads/2019/10/Screen-Shot-2019-10-29-at-3.32.28-PM.png?resize=768%2C546&ssl=1 768w, https://i0.wp.com/www.psychiatryeducationforum.com/wp-content/uploads/2019/10/Screen-Shot-2019-10-29-at-3.32.28-PM.png?w=1196&ssl=1 1196w” sizes=”(max-width: 1024px) 100vw, 1024px” /> <h3>Detailed answer is available at following…
Dr. Harvinder Singh, MD Admin, Psychiatry Education Forum Facebook Twitter Instagram Youtube Linkedin Physician’s Guide for Clinical Psychiatry Course Subscribers will have more detailed access…
(Q) 28 year old male with history of major depressive disorder, reports having sexual side effects on trial of fluoxetine, sertraline, mirtazapine and venlafaxine.…
This podcast will be summarized in the following sections: (1) Assessment: before initiation of Naltrexone XR (2) Clinical Opiate Withdrawal Scale (COWS) (3) Naltrexone (oral)…
The answer is available at our following two channels: (1) YouTube This podcast will answer the following six questions: (2) Physician’s Guide for Clinical Psychiatry…
YouTube Channel (Video Podcast): For Course Subscribers: Clozapine Interaction table PDF available for download (free preview available for a limited time only): https://psychiatryeducationforum.teachable.com/courses/451404/lectures/8430830 Subscribe to…
Answer is available in our next video podcast here: Detailed answer available for course subscribers here: https://mailchi.mp/ac53f9c8e8fb/antidepressants-and-risk-of-thrombocytopenia
Post your answers below We have summarized this topic in this short 20 min video podcast here: https://youtu.be/UXYBXOjUNuI
Post your answer by using “Leave a Comment” option below. More detailed answer is available here: https://mailchi.mp/62acf1868385/comparing-fda-approved-medications-bipolar-1-depressed
Answer posted here: https://mailchi.mp/2c27d4fc37d1/drug-interaction-hiv-medication-psychotropics
Cariprazine (Vraylar) was initially approved for acute treatment of manic or mixed episodes associated with bipolar I disorder in adults. This week FDA also approved…
Answer Posted: https://psychiatryeducationforum.teachable.com/courses/451404/lectures/10380068 Subscribe for similar clinically relevant topics and podcasts.
This podcast will summarize Clozapine-Induced Gastrointestinal Hypomotility (CIGH) in the following six sections:1. How clozapine can cause CIGH?2. Clinical signs of ileus states.3. Risk factors for CIGH…
Chapter: http://bit.ly/Comparing_Antidepressants_1 YouTube: https://youtu.be/lB3l77VA4bc Chapter: http://bit.ly/Comparing_Antidepressants_2 YouTube: https://youtu.be/u8WLCAcv4tE Subscribe for similar clinically relevant topics and podcasts.
Answer with detailed explanation is available in our following course chapter (available for free access): Subscribe for similar clinically relevant topics and podcasts.
This table will summarize the dose conversion between: (1) Oral Risperidone (Risp) (2) Oral Paliperidone (Invg) (3) Risperidone Consta (R. Cont) (4) Invega Sustenna (I.…
This is our first video podcast lecture. This podcast will compare Lithium, Depakote, Carbamazepine, Oxcarbazepine and Lamotrigine in following sections: FDA Indications. CANMAT and ISBD…
↓ ↓ Answer: 30 eGFR < 30 mL/min/1.73 m2: Metformin isContraindicated eGFR between 30-45 mL/min/1.73 m2 : Initiation of metformin is not recommended If eGFR falls…
Esketamine is a glutamate receptor modulator: acts as noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. On March 05, 2019: FDA approved Spravato (esketamine) nasal spray, as an…
Autism spectrum disorder is a neurodevelopmental disorder characterized by deficits in social communication and social reciprocity, as well as repetitive behavior and restricted interests. ↓…
↓ ↓ Answer: Fluoxetine. Detailed Explanation Posted in Following Course Updated Chapter: (3.4) ANTIDEPRESSANTS and Warfarin (Chapter Updated) https://psychiatryeducationforum.teachable.com/courses/physicians-guide-for-clinical-psychiatry/lectures/8430865 Dr. Harvinder Singh, M.D. (Admin & Course…
Patient with diagnosis of bipolar I disorder had remission of his recent manic episode with combination of mood stabilizer (lithium/ divalproex) and antipsychotic (risperidone/ olanzapine)…
A Systematic Review and Network Meta-Analysis conducted by Peng Xie et al. investigated the comparative efficacy and tolerability of adjunctive atypical antipsychotics for treatment-resistant depression.…
(Q.1): HOW TO CONVERT ORAL RISPERIDONE TO RISPERIDONE CONSTA? ORAL RISPERIDONE RISPERIDONE CONSTA 3 mg/day or less. 25 mg >3 to <5 mg/day or less…
This chapter will compare following three FDA approved medications for opioid use disorder: Methadone (MET). Buprenorphine/Nalaxone (BUP). Naltrexone injectable- Vivitrol (NTX). MET BUP NTX…
DEFINITION OF LOW-DOSE NALTREXONE (LDN): Naltrexone is used in 50- 100 mg daily dose for opioid use disorder treatment. LDN is 1/10th of…
BEFORE SCROLLING DOWN ==> SUBMIT YOUR ANSWERS FIRST 🙂 . . . . Answer 1: (e) None of the above. Typical Antipsychotics should be avoided…
MECHANISM OF HAIR LOSS: Depakote —> can result in biotin deficiency and low biotinidase enzyme activity —> results in alopecia (hair loss). Additional role…
MECHANISM OF ACTION: Partial agonist at 5-HT1A. Low affinity as antagonist for dopamine D2 auto-receptors. According to rat models: Repeated use of haloperidol —> result…
This is second part of our post on this topic. First part is available here: Antipsychotics Induced Weight Gain. This post will focus…
Weight gain is one of the untoward side effect of antipsychotic medications and the extent of weight gain varies among all antipsychotics. This post will…
BEFORE SCROLLING DOWN ==> SUBMIT YOUR ANSWERS FIRST 🙂 . . . . A is correct:Sertraline is more potent at blocking DA receptor…
Total VPA levels monitoring in patients with low albumin level may not represent correct VPA level. Hermida et al published this study…
BEFORE SCROLLING DOWN ==> SUBMIT YOUR ANSWERS FIRST 🙂 . . . . A Cochrane systematic review was done to answer this…
(1) * Deplin is a medical food containing L-methylfolate, the active dietary form of the vitamin B9 (folate).* EnLyte is an FDA-regulated prescription medication. This ensures prescribing uniformity and integrity, maintains your (the…
Therapeutic Drug Monitoring: Aripiprazole <img src=”https://psychiatryeducationforum.com/project1/wp-content/uploads/elementor/thumbs/0-ogfdvzu02tegyrenmh4w7eyg4fz8zzfh13uz94u7bc.jpeg” title=”0″ alt=”0″ /> <h4>Therapeutic drug monitoring have limited value in the clinical use of aripiprazole. It may be useful…
BEFORE SCROLLING DOWN ==> SUBMIT YOUR ANSWERS FIRST 🙂 . . . . REDUCED LAMOTRIGINE LEVELS Atazanavir/Ritonavir: may decrease lamotrigine plasma concentrations due…
CLINICAL RECOMMENDATIONS: (1) ANTIDEPRESSANT DOSING: ‘start low and go slow’ with antidepressants. Try not reach a therapeutic dose in patients with adequate tolerance.…
BEFORE SCROLLING DOWN ==> SUBMIT YOUR ANSWERS FIRST 🙂 . . . . Quetiapine is the drug of choice for…
FDA approved the first once monthly long acting injectable form of Risperidone: PERSERIS™ (in July 2018). INDICATION: Schizophrenia in adults. DOSAGE: 90 mg and 120…
BEFORE SCROLLING DOWN ==> SUBMIT YOUR ANSWERS FIRST 🙂 . . . . Tramadol is indicated for the management of moderate to moderately…
BEFORE SCROLLING DOWN ==> SUBMIT YOUR ANSWERS FIRST 🙂 . . . . Higher dose of prazosin may be needed for…
PART 1 is available here: Haloperidol Decanoate (PART 1) This part will focus on loading and conversion strategies for haloperidol decanoate. HOW…
BEFORE SCROLLING DOWN ==> SUBMIT YOUR ANSWERS FIRST 🙂 . . . . PHARMACOKINETICS: Peak Levels Reached by: 6 days after the injection. Half Life:…
BEFORE SCROLLING DOWN ==> SUBMIT YOUR ANSWERS FIRST 🙂 . . . . Prazosin is used for treatment of intrusive nightmares and flashbacks…
(1) Ideally obtain total serum LTG level at therapeutic dose before pregnancy. (2) If patient is seen during pregnancy: obtain levels as early as possible…
BEFORE SCROLLING DOWN ==> SUBMIT YOUR ANSWERS FIRST 🙂 . . . . SERTRALINE: Strongest dopamine reuptake blocker among SSRIs. Literature review found highest…
BEFORE SCROLLING DOWN ==> SUBMIT YOUR ANSWERS FIRST 🙂 . . . . Antipsychotics that Increases Prolactin (45 to >100 ng/ml) and Should…
Methadone: Drug Interactions BEFORE SCROLLING DOWN ==> SUBMIT YOUR ANSWERS FIRST 🙂 . . . . DECREASE METHADONE Carbamazepine CYP3A4…
Clozapine: Managing Side Effects By Dr. Harvinder Singh. Physicians are aware of serious side effects from clozapine including agranulocytosis, myocarditis, cardiomyopathy, pulmonary embolism and seizure…
Please do post your questions or comments below. Dr. Harvinder Singh, M.D. (Admin) Enroll in our online course to have access to all important clinically…
Q.8: Which of the following medication is FDA approved for treatment of Dementia associated with Parkinson’s Disease?(a) Donepezil(b) Galantamine(c) Rivastigmine(d) Memantine Answer: (c) Rivastigmine FDA…
Q.7. 40 year old male with history of major depression disorder presents for evaluation and management of recent increase in anxiety. Laboratory workup revealed abnormal liver…
Q.6: 45 year old male with history of depression, seizure disorder, hepatitis and coronary artery disease. He is interested in medication options of his recent increase…
Tasimelteon: Important Drug Interactions Q.2. Tasimelteon is a melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder.Addition of which of the following medication…
Answer: (b) Sertraline Read the following chapter in our online course: (15.1) Treatment of Depression after Traumatic Brain Injury. This chapter will answer above question…
The VAST-D Randomized Clinical Trial published in JAMA answered this question. This post will focus on details and findings of this trial. …
U.S. FDA Approves Mydayis™ (mixed salts of single entity amphetamine product) Shire plc (LSE: SHP, NASDAQ: SHPG) announced on June 20, 2017 that the U.S.…
This is the first and only FDA-approved product indicated for the treatment of adults with tardive dyskinesia. This post will summarize basic details regarding this medication.…
Donepezil, Rivastigmine & Galantamine: Use in Renal and Hepatic Impairment Donepezil Single doses of donepezil can be safely administered to patients with moderately…
Patient with treatment resistant schizophrenia is admitted for fifth time this year secondary to worsening of psychotic symptoms. He is compliant with medications and have…
BEFORE SCROLLING DOWN ==> SUBMIT YOUR ANSWERS FIRST 🙂 . . . .What is the Underlying Mechanism? SSRIs limit uptake of blood serotonin by platelets.…
40 year old patient with history of schizophrenia stabilized on clozapine presented with recent worsening of psychotic symptoms. He recently started smoking and initiated treatment…
Are Antidepressants Safe in Pregnancy? Q.1: Is first-trimester use of SSRIs associated with increased risk of birth defects? This study used the data from the Slone…
Antipsychotics use with Impaired Renal Function This post will summarize the use of individual antipsychotics in patient’s with impaired renal function. Medications Use in Impaired…
Cabergoline is preferred over Bromocriptine for its efficacy and favorable side effect profile (less risk of nausea compared to Bromocriptine). This post will summarize…
Psycho-Pharmacologic Management of Autism Spectrum Disorder Do you all agree with this algorithm. This algorithm is a condensed version of various articles (Please correct me…
Q: Patient on Valproate found to have high Ammonia level. What will you do next? (1) Is Patient Asymptomatic or Symptomatic (altered consciousness, confusion, nausea,…
SSRI (Selective Serotonin Reuptake Inhibitors): Important Facts to Know (1) Do SSRIs have Active Metabolites? Fluoxetine (Norfluoxetine with half life of 7–14 days). Note: R-norfluoxetine is…
The following two double blind randomized trails will answer this question. ARTICLE 1: This randomized, double-blind, placebo-controlled trial published by Calabrese et al…
Hydroxyzine: Important Eight Recommendations by European Medicines Agency (1) Hydroxyzine has the potential to block hERG channels and other types of cardiac channels, resulting…
FDA Approved Low Dose ZUBSOLV® (Buprenorphine and Naloxone) for Opioid Dependence Treatment Contents: 0.7 mg of buprenorphine and 0.18 mg of naloxone. Available Dose Strengths…
Antipsychotic Medications and the Risk of Seizures This study did a nested case-control analysis to investigate the association between antipsychotic drug use and the development…
Alcohol Withdrawal: Medications Comparison Chlordiazepoxide Diazepam Lorazepam Oxazepam Onset of Action Oral: ~30 min Oral (Rapid) and IV (Immediate) Oral (60 min) and IV (~20 min)…
Switching Dose from Oral Risperidone to Risperidone Long-Acting Injection Oral Risperidone Dose = Risperidone Long-Acting Injection 3 mg/day or less = 25 mg > 3 mg/day-…
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