Lithium is the oldest mood stabilizer approved for bipolar disorder and still is considered the gold standard treatment. Lithium is not protein bound, is not metabolized and close to 95% of it is excreted unchanged by kidney. Lithium induced nephrogenic diabetes insipidus is common and can present as polyuria. It is clinically important to have the knowledge of how to prevent and treat this common adverse events from lithium.
Let’s begin by answering this question first:
Answer: (c) Lithium Carbonate 600 mg once daily.
A twice-daily dose of lithium was of similar efficacy as the once-daily schedule but produces higher renal adverse effects that may be dose-related. Therefore, a single daily dose of lithium can be a viable method to reduce the side effects of lithium, which may lead to better patient compliance.
Reference: Singh LK, Nizamie SH, Akhtar S, Praharaj SK. Improving tolerability of lithium with a once-daily dosing schedule. Am J Ther. 2011 Jul;18(4):288-91. PMID: 20592663.
TOPICS DISCUSSED IN THIS LECTURE TODAY:
LITHIUM INDUCED POLYURIA
At Psychiatry Education Forum Academy, we believe that it is critical to periodically remind oneself of how to tackle the common as well as serious side effects of lithium. When it comes to side effects, we have seen among our colleagues, knowing what to look for and how to tackle each side effect, imparts a great deal of confidence that enables effective use of Lithium.
Psychiatry Education Forum Academy is excited to announce the release of our 4-days lecture series on Understanding Lithium’s Adverse Events Management: Here we will discuss the clinical details of how to Recognize, Manage, Monitor, and Prevent these adverse events from lithium.
THIS LECTURE SERIES IS FOR OUR ACADEMY MEMBERS ONLY
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