Omega-3 Fatty Acids for Depression?

Recently Omega-3 polyunsaturated fatty acids, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) have drawn the clinical attention for the treatment of major depressive disorder. The knowledge of omega-3-fatty acids is clinically relevant for medical professionals treating major depressive disorder.

Let’s Answer this Question first:

Which EPA/DHA ratio in Omega 3-Fatty Acid formulation is considered therapeutic for MDD?

Answer: (b) EPA/DHA > 2:1

According to recent International Society for Nutritional Psychiatry Research Practice Guidelines: EPA (eicosapentaenoic acid)/DHA (docosahexaenoic acid) ratio higher than 2 (EPA/DHA >2) are considered effective.

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This journal club will answer the following ten clinically relevant questions:

  1. Are omega-3 fatty acids effective as augmentation or as monotherapy for MDD management?

  2. What dose of omega-3 fatty acid is considered therapeutic for the treatment of MDD?

  3. What ratio of EPA/DHA is crucial for omega-3 fatty acids’s therapeutic benefit?

  4. Is pure EHA more efficacious than the combination of EHA/DHA for MDD?

  5. What is the recommended minimum duration of treatment with omega-3 fatty acid for the treatment of MDD?

  6. Is omega-3 fatty acid efficacious for recurrent depression?

  7. What are the common adverse events at the therapeutic dose of omega-3 fatty acid?

  8. What additional lab work is required when using the higher dosages of omega-3 fatty acid?

  9. How to ensure the omega-3 fatty acid’s product quality before buying?

  10. Do omega-3 fatty acid’s response in MDD have a relation with inflammatory biomarkers?

Omega-3 Fatty Acids for Major Depressive Disorder Treatment

ISNPR Practice Guidelines for Omega-3 Fatty Acids in the Treatment of Major Depressive Disorder

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