Omega-3 Fatty Acids for Depression?
Recently Omega-3 polyunsaturated fatty acids, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) have drawn the clinical attention for the treatment of major depressive disorder. The knowledge of omega-3-fatty acids is clinically relevant for medical professionals treating major depressive disorder.
Let’s Answer this Question first:
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Answer: (b) EPA/DHA > 2:1
According to recent International Society for Nutritional Psychiatry Research Practice Guidelines: EPA (eicosapentaenoic acid)/DHA (docosahexaenoic acid) ratio higher than 2 (EPA/DHA >2) are considered effective.
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This journal club will answer the following ten clinically relevant questions:
Are omega-3 fatty acids effective as augmentation or as monotherapy for MDD management?
What dose of omega-3 fatty acid is considered therapeutic for the treatment of MDD?
What ratio of EPA/DHA is crucial for omega-3 fatty acids’s therapeutic benefit?
Is pure EHA more efficacious than the combination of EHA/DHA for MDD?
What is the recommended minimum duration of treatment with omega-3 fatty acid for the treatment of MDD?
Is omega-3 fatty acid efficacious for recurrent depression?
What are the common adverse events at the therapeutic dose of omega-3 fatty acid?
What additional lab work is required when using the higher dosages of omega-3 fatty acid?
How to ensure the omega-3 fatty acid’s product quality before buying?
Do omega-3 fatty acid’s response in MDD have a relation with inflammatory biomarkers?
Omega-3 Fatty Acids for Major Depressive Disorder Treatment
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