Omega-3 Fatty Acids for Depression?

Recently Omega-3 polyunsaturated fatty acids, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) have drawn the clinical attention for the treatment of major depressive disorder. The knowledge of omega-3-fatty acids is clinically relevant for medical professionals treating major depressive disorder.

Let’s Answer this Question first:

Welcome to your Omega 3-FA MDD

Which EPA/DHA ratio in Omega 3-Fatty Acid formulation is considered therapeutic for MDD?

Answer: (b) EPA/DHA > 2:1

According to recent International Society for Nutritional Psychiatry Research Practice Guidelines: EPA (eicosapentaenoic acid)/DHA (docosahexaenoic acid) ratio higher than 2 (EPA/DHA >2) are considered effective.


This journal club will answer the following ten clinically relevant questions:

  1. Are omega-3 fatty acids effective as augmentation or as monotherapy for MDD management?

  2. What dose of omega-3 fatty acid is considered therapeutic for the treatment of MDD?

  3. What ratio of EPA/DHA is crucial for omega-3 fatty acids’s therapeutic benefit?

  4. Is pure EHA more efficacious than the combination of EHA/DHA for MDD?

  5. What is the recommended minimum duration of treatment with omega-3 fatty acid for the treatment of MDD?

  6. Is omega-3 fatty acid efficacious for recurrent depression?

  7. What are the common adverse events at the therapeutic dose of omega-3 fatty acid?

  8. What additional lab work is required when using the higher dosages of omega-3 fatty acid?

  9. How to ensure the omega-3 fatty acid’s product quality before buying?

  10. Do omega-3 fatty acid’s response in MDD have a relation with inflammatory biomarkers?

Omega-3 Fatty Acids for Major Depressive Disorder Treatment

ISNPR Practice Guidelines for Omega-3 Fatty Acids in the Treatment of Major Depressive Disorder



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  • 30+ Courses/Sections: Each chapter within these sections is of direct clinical relevance for your daily practice. 
  • Journal Club: we will post the most recently published psychiatry articles relevant to your daily clinical practice.
  • Coffee Club: contain short discussions with clinical experts in the field of psychiatry.
  • Essentials of Inpatient Psychiatry Book: All chapters from this book are included in the academy sections. 
  • Discussion Forum & Community: Connect with other medical professionals and discuss your difficult-to-treat clinical cases.
  • Conference Discounts: Academy members get discounted access at our conferences. 
  • Goal: is to have all important clinically relevant topics in one place for ease of access.


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