Answer: (b) Sertraline.
Warfarin has two isomers:
- S-isomer (three times more potent than R-isomer): metabolized by 2C9.
- R-isomer: metabolized by 1A2 (major) and 2C19 & 3A4 (minor)
—> monitor for antidepressants inhibiting 2C9 (and 1A2)
- 2C9 inhibition: —
- 1A2 inhibition: —
- Risk of interaction is Low: no clinical effects noted.
- Monitoring PT is recommended (may increase PT- not clinically significant in most)
- SERTRALINE APPEARS TO BE SAFE WITH WARFARIN.
WARFARIN & ANTIDEPRESSANTS
The following PEFA chapter will summarize the interaction of following antidepressants with warfarin:
- SSRIs: Fluoxetine, Fluvoxamine, Sertraline, Paroxetine, Citalopram & Escitalopram
- SNRIs: Venlafaxine, Duloxetine
- TCAs: Amitriptyline, Nortriptyline.
INTERESTED IN THIS DISCUSSION & MORE?
JOIN PSYCHIATRY EDUCATION FORUM ACADEMY MEMBERSHIP
This is a closed membership for medical professionals only.
- 30+ Courses/Sections: Each chapter within these sections is of direct clinical relevance for your daily practice.
- Journal Club: we will post the most recently published psychiatry articles relevant to your daily clinical practice.
- Coffee Club: contain short discussions with clinical experts in the field of psychiatry.
- Essentials of Inpatient Psychiatry Book: All chapters from this book are included in the academy sections.
- Discussion Forum & Community: Connect with other medical professionals and discuss your difficult-to-treat clinical cases.
- Conference Discounts: Academy members get discounted access at our conferences.
- Goal: is to have all important clinically relevant topics in one place for ease of access.
SUBSCRIBE TO OUR EMAIL NEWSLETTER: