Bupropion & Risk of Seizures
- With the IR formulation, the rate is 0.4% (4/1000) at doses of 300 to 450 mg/day.
- With the SR formulation, the rate is 0.1% (1/1000) at the target dose of 300 mg/day.
- Incidence of seizure with bupropion XL has not been evaluated.
- This incidence of seizures may exceed that of other antidepressants by as much as 4-fold.
- Incidence increases to ~10 folds between 450-600 mg/day dose.
SOÂ THE RISK OF SEIZURE APPEARS TO BE STRONGLY ASSOCIATED WITH DOSE.Â
FOR ACADEMY MEMBERS:
Bupropion & Risk of Seizures
This chapter will summarize the topic in (1) Incidence risk, (2) Risk Factors, & (3) Management.
This chapter is summarized in following sections:
- Incidence of seizure risk with Bupropion?
- What Patient Factors may increase the risk of seizure with bupropion?
- Which Clinical Situations are associated with increased risk of seizure?
- What are the recommendations for reducing the risk of seizure with Bupropion?
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