- With the IR formulation, the rate is 0.4% (4/1000) at doses of 300 to 450 mg/day.
- With the SR formulation, the rate is 0.1% (1/1000) at the target dose of 300 mg/day.
- Incidence of seizure with bupropion XL has not been evaluated.
- This incidence of seizures may exceed that of other antidepressants by as much as 4-fold.
- Incidence increases to ~10 folds between 450-600 mg/day dose.
SO THE RISK OF SEIZURE APPEARS TO BE STRONGLY ASSOCIATED WITH DOSE.
FOR ACADEMY MEMBERS:
Bupropion & Risk of Seizures
This chapter is summarized in following sections:
- Incidence of seizure risk with Bupropion?
- What Patient Factors may increase the risk of seizure with bupropion?
- Which Clinical Situations are associated with increased risk of seizure?
- What are the recommendations for reducing the risk of seizure with Bupropion?
INTERESTED IN LEARNING MORE?
JOIN PSYCHIATRY EDUCATION FORUM ACADEMY MEMBERSHIP
This is a closed membership for medical professionals only.
- 30+ Courses/Sections: Each chapter within these sections is of direct clinical relevance for your daily practice.
- Journal Club: we will post the most recently published psychiatry articles relevant to your daily clinical practice.
- Coffee Club: contain short discussions with clinical experts in the field of psychiatry.
- Essentials of Inpatient Psychiatry Book: All chapters from this book are included in the academy sections.
- Discussion Forum & Community: Connect with other medical professionals and discuss your difficult-to-treat clinical cases.
- Conference Discounts: Academy members get discounted access at our conferences.
- Goal: is to have all important clinically relevant topics in one place for ease of access.