Bupropion & Risk of Seizures

Q: Bupropion is contraindicated in patients with seizure disorder. What is the maximum recommended total daily dose to reduce the risk of seizure with Bupropion?

  • With the IR formulation, the rate is 0.4% (4/1000) at doses of 300 to 450 mg/day.
  • With the SR formulation, the rate is 0.1% (1/1000) at the target dose of 300 mg/day.
  • Incidence of seizure with bupropion XL has not been evaluated.
  • This incidence of seizures may exceed that of other antidepressants by as much as 4-fold.
  • Incidence increases to ~10 folds between 450-600 mg/day dose.

SO THE RISK OF SEIZURE APPEARS TO BE STRONGLY ASSOCIATED WITH DOSE. 

FOR ACADEMY MEMBERS:

Bupropion & Risk of Seizures

This chapter will summarize the topic in (1) Incidence risk, (2) Risk Factors, & (3) Management.

This chapter is summarized in following sections:

  • Incidence of seizure risk with Bupropion?
  • What Patient Factors may increase the risk of seizure with bupropion?
  • Which Clinical Situations are associated with increased risk of seizure?
  • What are the recommendations for reducing the risk of seizure with Bupropion?

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