Augmentation Strategies for Clozapine-Resistant Schizophrenia?
Clozapine is considered a gold-standard medication for treatment-resistant schizophrenia, but close to 50% of these patients on clozapine may show poor or no response. What…
Tag: clozapine
Medications Induced Neutropenia: Avoid them with Clozapine.
Neutropenia is the single most important risk factor for infection and Clozapine is well known for the increased for neutropenia. This neutropenia risk will increase…
Clozapine and New-Onset Obsessions
Clozapine as a treatment option has many strengths. But it also has some weaknesses. This week I had a patient who has been stable on…
Clozapine Drug-Drug Interactions
Choose your answer first before scrolling down…. <strong>Answer: CYP1A2 interaction</strong></p><ul><li>Clozapine is extensively metabolized in the liver via the cytochrome P450 system. </li><li><strong>Cytochrome P450 isoenzyme 1A2…
Clozapine, REMS and COVID-19
FDA issued the statement on March 22, 2020 regarding the patient access to REMS (Risk Evaluation and Mitigation Strategy) medications like clozapine during COVID-19 public…
Psychotropic Drug Interactions: Clozapine and GERD Medications.
Detailed answer is available in our first email of Psychotropics Drug-Drug Interactions lecture series:- <a data-elementor-open-lightbox=”” href=”https://app.getresponse.com/view/a62b/EwvVVzw/whArc/email-message/bhdkY” target=”_blank” rel=”noopener noreferrer”> <img width=”599″ height=”638″ src=”https://psychiatryeducationforum.com/project1/wp-content/uploads/2020/01/Screen-Shot-2020-01-08-at-1.20.08-PM.png” alt=””…
Restarting Clozapine After Missed Dose
Answer: <img width=”1024″ height=”729″ src=”https://psychiatryeducationforum.com/project1/wp-content/uploads/2019/10/Screen-Shot-2019-10-29-at-3.32.28-PM-1024×729.png” alt=”” srcset=”https://i0.wp.com/www.psychiatryeducationforum.com/wp-content/uploads/2019/10/Screen-Shot-2019-10-29-at-3.32.28-PM.png?resize=1024%2C729&ssl=1 1024w, https://i0.wp.com/www.psychiatryeducationforum.com/wp-content/uploads/2019/10/Screen-Shot-2019-10-29-at-3.32.28-PM.png?resize=300%2C213&ssl=1 300w, https://i0.wp.com/www.psychiatryeducationforum.com/wp-content/uploads/2019/10/Screen-Shot-2019-10-29-at-3.32.28-PM.png?resize=768%2C546&ssl=1 768w, https://i0.wp.com/www.psychiatryeducationforum.com/wp-content/uploads/2019/10/Screen-Shot-2019-10-29-at-3.32.28-PM.png?w=1196&ssl=1 1196w” sizes=”(max-width: 1024px) 100vw, 1024px” /> <h3>Detailed answer is available at following…
Clozapine-Induced Gastrointestinal Hypomotility
This podcast will summarize Clozapine-Induced Gastrointestinal Hypomotility (CIGH) in the following six sections:1. How clozapine can cause CIGH?2. Clinical signs of ileus states.3. Risk factors for CIGH…
Lamotrigine to Augment Clozapine: 6 Clinical Points to Consider.
  #1: Make sure that blood clozapine levels are in the therapeutic range and the patient is taking the maximum tolerable doses of clozapine over at least 18-24…
Clozapine: Managing Side Effects
Clozapine: Managing Side Effects By Dr. Harvinder Singh. Physicians are aware of serious side effects from clozapine including agranulocytosis, myocarditis, cardiomyopathy, pulmonary embolism and seizure…
Clozapine Associated Agranulocytosis Monitoring
Patient with treatment resistant schizophrenia is admitted for fifth time this year secondary to worsening of psychotic symptoms. He is compliant with medications and have…
What Medications Affect Clozapine Levels?
40 year old patient with history of schizophrenia stabilized on clozapine presented with recent worsening of psychotic symptoms. He recently started smoking and initiated treatment…
Reasons for Clozapine Discontinuation and No Rechallange
Reasons for Clozapine Discontinuation and No Rechallange CARDIAC SIDE EFFECTS QTc > 500 msec —> Discontinue Clozapine. Myocarditis (Increased Heart Rate, ST elevation, Troponins >2…