Treatment Options for Clozapine-Resistant Schizophrenia?
Clozapine is considered a gold-standard medication for treatment-resistant schizophrenia, but close to 50% of these patients on clozapine may show poor or no response. What treatment options are available for clozapine-resistant schizophrenia population?
This is what Dr. Harvinder Singh discussed in his Grand Round presentation on Nov 14, 2022:
Let’s begin by answering this question first:
Answer: Antipsychotics
Here is one slide from this presentation:
CLOZAPINE RESISTANT SCHIZOPHRENIA: AUGMENTATION WITH ANTIPSYCHOTICS
FOR ACADEMY MEMBERS:
TREATMENT OPTIONS FOR CLOZAPINE-RESISTANT SCHIZOPHRENIA?
This discussion is summarized in the following clinically relevant sections:
(1) Consider these five factors before augmentation.
(2) Role of clozapine level monitoring.
(3) What is an adequate duration of clozapine trial?
(3) Clozapine augmentation options for:
- Positive symptoms
- Negative symptoms
- Clozapine refractory suicidality
- Clozapine refractory aggression
- Role of neuromodulation
- Is Psychotherapy beneficial?
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