Trazodone Once-A-Day (TzOAD) for MDD?
Trazodone belongs to a class of antidepressant medications called serotonin antagonists and reuptake inhibitors (SARIs). Traozodone is used more for insomnia treatment compared to MDD (major depressive disorder): due to the risk of side effects with higher doses.
On May 12, 2023: this first observational, prospective, single-group, multicentre, international study was published in Neuropsychiatr Dis Treat. showing the efficacy of Trazodone Once-A-Day (TzOAD) monotherapy for MDD treatment over a 24-week period.
Sustained improvements were found over a period of 24 (±4) weeks in:
- Clinical response
- Functional impairment
- Depressive symptoms, and
- Health-related QoL
Psychiatry Education Forum Academy has summarized this topic in the following sections:
- How is Trazodone different from SSRIs and SNRIs?
- Which mechanism of action is responsible for antidepressant efficacy and risk of adverse events?
- What dose of Trazodone is effective for MDD treatment?
- What dose of Trazodone is effective for insomnia treatment (off-label)?
- Is a hypnotic dose of Trazodone effective for MDD treatment?
- Trazodone: Immediate release formulation versus once-a-day formulation
- How to initiate and titrate Trazodone Once-A-Day for MDD treatment?
HERE IS ONE SLIDE FROM ACADEMY PRESENTATION:
How Trazodone’s Mechanism of Action Changes with Each Dose:
[FOR ACADEMY MEMBERS]
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