Xanomeline-Trospium Chloride (KarXT) for Schizophrenia
Introducing KarXT: A New Paradigm
on May 1, 2024, JAMA Psychiatry published the positive results of EMERGENT-3 trials for this potential non-dopaminergic medication for schizophrenia.
KarXT is a combination of two drugs: xanomeline and trospium chloride. This innovative therapy represents a significant departure from traditional antipsychotic treatments.
- Xanomeline, a muscarinic receptor agonist, targets the cholinergic system in the brain, which is believed to play a crucial role in the symptoms of schizophrenia.
- Trospium chloride, on the other hand, is a muscarinic receptor antagonist that does not cross the blood-brain barrier, mitigating the peripheral side effects of xanomeline without diminishing its central therapeutic effects.
(1) KarXT: Likely Mechanism of Action:
WATCH YOUTUBE VIDEO FOR DETAILS:
(2) KarXT: How to Dose?
FOR ACADEMY MEMBERS:
Xanomeline-Trospium Chloride (KarXT) for Schizophrenia
This video discussion is summarized in the following sections:
- Mechanism of Action: how is this different from other antipsychotics?
- Dosing: How to Dose & Titrate?
- Effectiveness: is this effective for both positive and negative symptoms of schizophrenia?
- Response Time: How early is the response seen with KarXT?
- Common side effects
- What is the risk of EPS, Weight Gain and Somnolence?
- Results from EMERGENT-3 trial (Phase 3 Double-blind, Randomized, Placebo-controlled trial): published in JAMA Psychiatry on May 1, 2024.
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