Which Antiepileptics are Preferred in Pregnancy?

When managing epilepsy in pregnant individuals, the choice of antiepileptic drugs (AEDs) plays a critical role in optimizing maternal and fetal outcomes. A recent study published in The Journal of Clinical Psychiatry reviewed the association between various AEDs and the risk of major congenital malformations.

The study found that

  • Lamotrigine and Levetiracetam were associated with a lower risk of congenital malformations, making them preferred options for women of childbearing age and those who are pregnant.
  • In contrast, Valproate showed a significantly higher risk of major congenital malformations, reinforcing the recommendation to avoid its use during pregnancy when possible.

WATCH SHORT VIDEO SUMMARY:

The above video is from our Academy’s monthly summary of recently published, clinically relevant articles.

This month session summarized the following topics:

(A) WOMEN’S MENTAL HEALTH:

  • Is Ketamine Safe in Pregnancy?
  • Which Antiepileptics are Preferred in Pregnancy?

(B) MDD + PTSD:

  • Can Prazosin Augmentation help in patient with MDD with history of Trauma ?

(C) PSYCHOPHARMACOLOGY ADVERSE EVENTS:

  • Can Zuranolone Impact Next-Day Driving, when used for Post-Partum Depression?

(D) PSILOCYBIN VS ANTIDEPRESSANTS:

  • Which one is better for Moderate to Severe MDD: Psilocybin or Antidepressants

(E) INSOMNIA & RELATED DISORDERS:

  • Lemborexant Safety with Comorbid Moderate to Severe COPD

(F) SCHIZOPHRENIA PSYCHOPHARMACOLOGY:

  • Comparing Antipsychotics & Pneumonia Risk: Which one to Avoid?

(G) VAPPING CESSATION:

  • New Potential Medication for Vaping Cessation.

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