Lamotrigine Dosing in Pregnancy & Postpartum
Let’s begin by answering this question first:
Answer: Gradual increase in dose from first to third trimester; and dose taper within three days of delivery
- The serum lamotrigine concentration will decrease from the first trimester and reaches its lowest concentration by the mid-third trimester. Both lamotrigine total and free clearance increased throughout pregnancy with a peak of 94% (total) and 89% (free) in the third trimester. This results in a decrease in lamotrigine level.
Psychiatry Education Forum Academy’s following chapter discussion will answer the following clinically relevant questions:
LAMOTRIGINE DURING PREGNANCY:
Q.1: When to first check serum lamotrigine level?
Q.2: How often to check lamotrigine levels during pregnancy?
Q.3: Does serum lamotrigine level change during pregnancy?
Q.4: How to dose lamotrigine during pregnancy?
LAMOTRIGINE AFTER DELIVERY:
Q.5: How to dose lamotrigine after delivery?
Q.6: How often to check lamotrigine levels after delivery?
Lamotrigine Use During Pregnancy & Postpartum
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