[Journal Club #6 + #7]: Two New Schizophrenia Medications with Novel Mechanism of Action

Dr. Harvinder Singh June 18, 2021

Today we posted the sixth and seventh journal club in PEFA Journal Club’s discussion series, discussing the following two newer antipsychotics for schizophrenia treatment:

(A) JOURNAL CLUB #6:

Journal Club #6:

Efficacy and Safety of Lumateperone for Treatment of Schizophrenia: A Randomized Clinical Trial.

Article: JAMA Psychiatry . 2020 Apr 1;77(4):349-358.

This journal club will be summarized in the following topics/questions:

  1. Lumateperone: Mechanism of action.
  2. Recommended dosage and titration.
  3. Lumateperone 28 mg vs 42 mg vs 84 mg: which one is preferred?
  4. When is the onset of response with Lumateperone?
  5. Lumateperone: Common adverse events.
  6. Association of Lumateperone with EPS, metabolic side effects, QTc prolongation and increase in suicidal ideations?
  7. How Lumateperone compares with other antipsychotics in terms of effect size for reduction in PANSS total symptoms?

FOR PEFA MEMBERS ONLY:

WATCH JOURNAL CLUB #6 DISCUSSION

(B) JOURNAL CLUB #7:

Journal Club #7:

A Non-D2-Receptor-Binding Drug for the Treatment of Schizophrenia.

Article: N Engl J Med. 2020 Apr 16;382(16):1497-1506. 

This journal club will discuss the basics of SEP-363856: Non–D2-Receptor-Binding Medication for Schizophrenia Treatment.

  1. Mechanism of Action for SEP-363856.
  2. Efficacy in Schizophrenia: PANSS Total, Positive, Negative and General Psychopathology scale.
  3. Side Effects Profile: Sleep, EPS, QTc Prolongation, Body Weight, and Metabolic Parameters.

FOR PEFA MEMBERS ONLY:

WATCH JOURNAL CLUB #7 DISCUSSION

Psychiatry Education Forum’s Journal Club is an additional feature for PEF Academy’s members. All academy members will be automatically enrolled in this journal club.

Here we post the most recently published psychiatry articles relevant to your daily clinical practice with CME credits available for selective journal club activities. 

READ JOURNAL CLUB SCHEDULE

CME ACCREDITATION:

4.75 AMA PRA Category 1 Credits Available from June 26, 2021

→ CME Credits will increase with our upcoming journal club video discussions.

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of PeerPoint Medical Education Institute, LLC and Psychiatry Education Forum LLC. The PeerPoint Medical Education Institute, LLC is accredited by the ACCME to provide continuing medical education for physicians.

The PeerPoint Medical Education Institute, LLC designates this enduring activity for a maximum of 4.75 AMA PRA Category 1 Credit(s)TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Accreditation & Designation Statements and Disclosure Report:

READ REPORT

INTERESTED IN JOINING THIS JOURNAL CLUB DISCUSSION SERIES?

JOIN PSYCHIATRY EDUCATION FORUM ACADEMY MEMBERSHIP

This is a closed membership for medical professionals only.

  • 30+ Courses/Sections: Each chapter within these sections is of direct clinical relevance for your daily practice. 
  • Journal Club: we will post the most recently published psychiatry articles relevant to your daily clinical practice.
  • Coffee Club: contain short discussions with clinical experts in the field of psychiatry.
  • Essentials of Inpatient Psychiatry Book: All chapters from this book are included in the academy sections. 
  • Discussion Forum & Community: Connect with other medical professionals and discuss your difficult-to-treat clinical cases.
  • Conference Discounts: Academy members get discounted access at our conferences. 
  • Goal: is to have all important clinically relevant topics in one place for ease of access.
 
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