Clozapine Withdrawal: Cholinergic Rebound
Clozapine, a second-generation antipsychotic medication, is often prescribed for individuals with schizophrenia who have not responded to other treatments. While it can be highly effective in managing symptoms, discontinuing clozapine can lead to a range of withdrawal effects, including a phenomenon known as cholinergic rebound.
Clozapine withdrawal, like withdrawal from many psychotropic medications, can be a challenging and potentially risky process. The concept of cholinergic rebound adds another layer of complexity to this journey, highlighting the intricate interplay between neurotransmitter systems in the brain.
CLINICAL PRESENTATION OF CHOLINERGIC REBOUND AFTER CLOZAPINE DISCONTINUATION:
NEW LECTURE ADDED FOR ACADEMY MEMBERS:
This session will be summarized into following four sections:
(1) Types of Clozapine Withdrawal Syndromes
(2) Clozapine Withdrawal Cholinergic Rebound: Clinical Signs & Symptoms.
(3) Management Options: Which medications can help?
(4) Prevention Strategies
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