Antipsychotics vs Mood Stabilizers for Acute Mania in Children & Adolescents: What Does the Latest Research Say?
The treatment of acute mania in children and adolescents remains a challenging clinical decision, often requiring a balance between efficacy and tolerability. While both antipsychotics and mood stabilizers are commonly used, recent research published in the Journal of the American Academy of Child & Adolescent Psychiatry (August 2024) sheds light on their comparative effectiveness and safety.
Here are one of the key takeaways:
–> Following 6 Treatments Performed Better than Placebo in Manic Response:
- Risperidone
- Olanzapine
- Aripiprazole
- Quetiapine
- Asenapine
- Lithium
–> Among Second Generation Antipsychotics: Ziprasidone was not found significant.
–> Following among mood stabilizers were not found significant:
- Topiramate
- Oxcarbazepine
- Valproate
Here is one slide from our academy’s chapter on this topic:
If you’re looking for an in-depth analysis of this study, check out our new Academy Chapter:
ANTIPSYCHOTICS VS MOOD STABILIZERS:
FOR ACUTE MANIA IN CHILDREN & ADOLESCENTS
In this chapter, Dr. Harvinder Singh will cover the following key sections to enhance your understanding:
(1) Early vs Late Onset Bipolar Disorder: What’s the difference?
(2) Treating Manic Symptoms:
- Preferred treatments
- Which ones to avoid
- Comparing treatments as individual options and as a class
(3) Response with Manic Episode Treatment:
- Best treatment options
- Treatments to avoid
- Comparative analysis
(4) Efficacy for Depressive Symptoms: Which treatments are effective?
(5) Improving Functionality: Which treatments work best?
(6) Lower Dropout Rates:
- Due to inefficacy
- For any reason
- Due to adverse events
(7) Adverse Events Comparison:
- Prolactin elevation
- BMI & weight changes
- Cholesterol, triglycerides, glucose changes
- Appetite increase, nausea, sedation
- Extrapyramidal symptoms (EPS)
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