Understanding Cardiac Risk with Lamotrigine

Lamotrigine, commonly used in the management of bipolar disorder and epilepsy, has been associated with certain cardiac risks. The primary concern revolves around its potential to cause heart rhythm abnormalities, particularly in patients with pre-existing cardiac conditions.

Watch the following YouTube video (which is one of our academy chapter) summarizing this clinically relevant topic in the following sections:

(1) What is the Mechanism behind this cardiac risk?
(2) Which patient population is at risk?
(3) Who needs EKG before initiating lamotrigine?
(4) Which EKG findings warrants against starting lamotrigine?
(5) When to repeat the EKG during lamotrigine treatment?
(6) How to educate your patients?

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Valproate

  1. Valproate & Thrombocytopenia 
  2. Valproate & Hair Loss
  3. Valproate & High Ammonia
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Lamotrigine

  1. Lamotrigine & Rashes: Treatment & Differentiating Factors 
  2. Lamotrigine & Cardiac Risk

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  • Topiramate and Cognitive-Related Dysfunction

Hydroxyzine

  • Hydroxyzine and QTc Prolongation Serious

Rashes Associated with Mood Stabilizers

  1. Stevens-Johnson Syndrome & Toxic Epidermal Necrolysis
  2. Rash Evaluation & Diagnosis
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