Sulforaphane for Negative Symptoms of Schizophrenia
Negative symptoms of schizophrenia—such as blunted affect, avolition, and social withdrawal—are often resistant to standard antipsychotic treatment and remain a major unmet clinical need.
Recent research has explored sulforaphane (SFN), a compound found in cruciferous vegetables like broccoli sprouts, as a potential adjunctive therapy. Through its antioxidant, anti-inflammatory, and epigenetic effects, SFN may improve specific negative symptoms without affecting positive symptoms or global functioning.Â
A 24-week randomized controlled trial demonstrated significant improvements in emotional withdrawal and blunted affect.
📣 New Chapter Now Available:
Sulforaphane for Negative Symptoms of Schizophrenia
We’ve just released a new chapter for our academy members, where we discussed:
The biological rationale for sulforaphane in schizophrenia
Key findings from recent clinical trials (including 2022 & 2025 RCTs)
Symptom-specific improvements and clinical relevance
Role of biomarkers like SOD and hsCRP in predicting treatment response
Practical guidance for clinicians on dosing, sourcing, and patient selection
Here is one slide from this presentation explaining the basics of Sulfraphane:
FOR ACADEMY MEMBERS:
We continue to review and summarize clinically relevant research to support your daily practice.
INTERESTED IN ACCESS TO THIS & OTHER CLINICALLY RELEVANT LECTURE SERIES?
JOIN ACADEMY MEMBERSHIP:
This is a closed membership for medical professionals only.
- 400+ Clinically Relevant Chapters: Each chapter within these sections is of direct clinical relevance for your daily practice. (Table of Content)
- Journal Club: we will post the most recently published psychiatry articles relevant to your daily clinical practice. (Read Content)
- Clinical Case Discussion: Dr. Singh (Psychiatry) and Dr. Kaur (Family Medicine) discuss clinical cases to integrate the clinical cases from Psychiatry and Medicine. (Read Content)
- Monthly Insights: Gain access to our monthly sessions featuring the latest on recent publications, new medication approvals, FDA updates, and more. (Monthly Insights)
- Discussion Forum & Community: Connect with other medical professionals and discuss your difficult-to-treat clinical cases. (Academy Network)
- Goal: is to have all important clinically relevant topics in one place for ease of access.
DISCOUNTS AVAILABLE FOR: Residents & Students ONLY.
Email us your student information (program information and way to confirm your student status) to: [email protected]
© 2025 All Rights Reserved.
