Managing Antidepressant Adverse Events
Thirty-one point-of-care chapters on what to do when the antidepressant causes the problem — recognition, differential, and a management ladder for each adverse effect, built for the clinician who has eight minutes and a patient waiting.
All seven parts are live — thirty-one chapters published, three of them free to read.
What this course is for
Most antidepressant education answers the question of what to prescribe. This series answers the harder question that follows: the patient is on the drug, something has gone wrong, and you have to decide within the visit whether it is the illness, the medication, or something else entirely — and what to do about it.
Every chapter is built around the same clinical question. Is it the drug or the disease? Because that single discrimination determines whether you increase the dose, reduce it, add something, switch, or stop — and getting it backwards is how a treatable adverse effect becomes a treatment failure.
Decision-first structure
Bottom line up front, then the differential, then a numbered action ladder. The answer is in the first screen, not the last.
Numbers with denominators
Every incidence and mortality figure names its study population. Where the evidence is weak or contested, the chapter says so.
Built to use, not to read
Patient counselling scripts and copy-paste EMR notes in every chapter, so the work of the visit is already drafted.
📅 The September series
Every chapter of this course published in September 2026. All seven parts are now live, from serotonin syndrome through to the closing quick-reference matrix.
Members get each part the day it publishes, at no additional cost, along with every other course in the Academy.
The 31 chapters
Serotonergic & Neuropsychiatric Effects
- 1Serotonin Syndrome
- 2Activation Syndrome & Treatment-Emergent Suicidality
- 3Antidepressant-Induced Akathisia
- 4Treatment-Emergent Mania & the Bipolar SwitchFree
- 5Tremor & Myoclonus
- 6Bruxism & Jaw Clenching
- 7Dystonia, Parkinsonism & Tardive Dyskinesia
GI, Sleep & Affect
- 8Nausea, Dyspepsia, Diarrhea & Dry Mouth
- 9Insomnia, Vivid Dreams & REM Sleep Effects
- 10Sedation & Daytime Somnolence
- 11Emotional Blunting, Apathy & Cognitive EffectsFree
Metabolic, Sexual & Long-Term
- 12Weight Gain & Appetite Change
- 13Sexual Dysfunction & PSSD
- 14Falls, Fractures & Bone Health
Cardiac, Autonomic & Bleeding
- 15QTc Prolongation, Tachycardia & Cardiac Conduction
- 16SNRI-Associated Hypertension
- 17Orthostatic Hypotension & Dizziness
- 18Antidepressant-Induced Excessive Sweating (ADIES)
- 19Urinary Retention & Incontinence
- 20Bleeding Risk: GI, Perioperative & Anticoagulant Co-PrescriptionFree
Laboratory, Stopping & Switching
- 21Hyponatremia & SIADH
- 22Transaminitis & Drug-Induced Liver Injury
- 23Discontinuation Syndrome & Hyperbolic Tapering
- 24Switching & Cross-Taper Safety
Agent-Specific Sets
- 25The Bupropion Set: Seizure Risk & Lowered Seizure Threshold — Bupropion and Beyond
- 26The Mirtazapine Set: Sedation, Appetite & Rare Neutropenia
- 27The Serotonin Modulator Set: Trazodone, Vilazodone & Vortioxetine
- 28The TCA Set: Anticholinergic Burden, Conduction Delay & Overdose Lethality
- 29The MAOI Set: Hypertensive Crisis, Tyramine & Washout Windows
Uncommon but Important + Quick Reference
- 30Rare but Serious: Angle-Closure Glaucoma, SJS/TEN, Blood Dyscrasias, Rhabdomyolysis, Hyperprolactinemia & Alopecia
- 31Quick-Reference Matrix: Antidepressant Adverse Event Grid
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