Ranking Antidepressants for Adolescent Depression Based on New Meta-Analysis
Our academy’s most recent chapter has reviewed the findings from a large network meta-analysis and systematic review involving 15 randomized controlled trials and over 12,000 adolescents, comparing the efficacy and safety of various antidepressants in treating Major Depressive Disorder (MDD) in adolescents.
💊 Clinical Highlights:
✅ Escitalopram – Best option when functional recovery is the primary treatment goal.
✅ Sertraline – Most effective for reducing overall illness severity.
✅ Fluoxetine – A good fit for adolescents with hypersomnia and favorable safety.
⚠️ Paroxetine – Strong efficacy on some measures but limited by side effects.
🌙 Agomelatine – Promising option with a unique melatonergic mechanism of action.
📖 Want to Go Deeper?
Academy members can access the full chapter with detailed breakdowns of each medication’s performance with following table of content:
Understanding the Difference Between Adolescent & Adult Depression
How symptom presentation, neurobiology, and treatment response differ.Antidepressants Ranking: Symptom Severity Reduction
Which antidepressants show the greatest improvement in depressive symptoms?Antidepressants Ranking: Functional Improvement
How antidepressants compare in helping adolescents regain function in daily life.First-Line Antidepressant for MDD in Adolescents
Evidence-backed recommendations for initial treatment choice.Best Choice When Rapid Response is Needed
Which antidepressants demonstrate faster onset of action?Best Option for Adolescents with Hypersomnia
Tailoring pharmacologic choices based on symptom subtype.Is Paroxetine a Good First-Line Option?
Reviewing the evidence, risks, and benefits.Safety Considerations in Treatment Planning
Evaluating tolerability and adverse effect profiles.Final Summary: Balancing Efficacy and Safety
Creating a practical, patient-centered information based on current data.
Compararing Antidepressant Medication for Adolescent Depression
We continue to review and summarize clinically relevant research to support your daily practice.
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