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Psychopharmacology in Medical Conditions — Rapid Decision Guide
Psychopharmacology with Hepatic Impairment
Members-only reference · text-based
In liver disease, every psychotropic decision turns on two independent questions — how much to reduce the dose, and whether the drug itself can injure the liver. This course answers both, drug class by drug class, in a format built for the point of care.
Psychopharmacology with Hepatic Impairment is the third entry in the Rapid Decision Guide series — a members-only clinical reference for prescribers treating psychiatric illness in patients with compromised livers. Across twelve chapters and five sections it moves from the foundational framework (Child-Pugh for dosing, MELD for transplant, and the two-axis model of clearance versus hepatotoxicity), through class-by-class dosing (antidepressants, antipsychotics, mood stabilizers, benzodiazepines, and stimulants), into the high-risk situations (drug-precipitated hepatic encephalopathy, the hepatotoxic watchlist, and alcohol-associated liver disease), and closes with a single-page quick-reference dosing table.
Every dosing figure is verified against the current FDA label. Every chapter ends the same way: a copy-paste documentation block, the red-flag stops that should make you reconsider, and a plain-language patient script.
Built for the moment you're writing the order — not the literature review afterward. Scannable tables, one clear recommendation per decision, and the reasoning kept to what changes what you do.
Start free — two open chapters
The Hepatic Decision Framework
FreeStart here: Child-Pugh versus MELD, why Phase I oxidation falls before Phase II glucuronidation, and the two-axis model that organizes the entire course. Read it →
Benzodiazepines & Sedative-Hypnotics — the LOT Rule
FreeThe single most-used rule in liver disease: lorazepam, oxazepam, temazepam — the glucuronidated agents to reach for, and the oxidized ones to avoid. Read it →
Read every chapter
Unlock all twelve chapters — and the rest of the Rapid Decision Guide series — with an Academy membership.
View membership options Already a member? Open the full course →Part of the Rapid Decision Guide series — psychopharmacology for the medically complex patient. Companion courses cover cardiac and renal impairment.
Foundations
Valproate: The Critical Drug
Dosing by Drug Class
High-Risk Decisions
Quick Reference