Managing Clozapine Adverse Events

PSYCHIATRY EDUCATION FORUM ACADEMY'S

UNDERSTANDING THE BASICS & BEYOND

Introduction:

Clozapine was FDA-approved for treatment-refractory schizophrenia in 1989 and has remained the gold standard treatment since then for this indication. Clozapine has established efficacy in both short and long-term treatment for schizophrenia & also improves patients’ functioning and quality of life.

Despite this Clozapine is underutilized due to concerns from an adverse events standpoint. Historically the focus has been on hematologic concerns from clozapine.

It is important for medical professionals to be aware of the presentation of symptoms, diagnostic findings, and management of each adverse events. This educational activity will educate practitioners about these adverse events so that they feel confident in weighing risks and benefits and consider prescribing clozapine to this treatment-resistant schizophrenia population.

Educational Objectives:

In the following lecture series by Psychiatry Education Forum Academy, Dr. Harvinder Singh will discuss the hematologic, cardiac, neurological, and gastro-intestinal adverse events with clozapine.

EDUCATIONAL OBJECTIVES:

To learn the types of clozapine’s adverse events.
Relationship of these adverse events with clozapine’s dose and duration of treatment.
Evaluation and Management of clozapine’s adverse events.
Discuss monitoring protocols with clozapine’s hematologic and cardiac adverse events.
Learning when to re-challenge vs not re-challenge with clozapine?

LECTURE SCHEDULE:

(1) CLOZAPINE SIDE EFFECTS: HEMATOLOGIC

Here is one of the clinically relevant slide from this discussion:

MANAGEMENT OPTION FOR: ANC 500-999/uL DURING CLOZAPINE TREATMENT:

(2) CLOZAPINE SIDE EFFECTS: CARDIAC

Here is one of the clinically relevant slide from this discussion:

CLOZAPINE DISCONTINUATION & RECHALLENGE WITH MYOCARDITIS

(3) CLOZAPINE SIDE EFFECTS: NEUROLOGICAL

Here is one of the clinically relevant slide from this discussion:

CLOZAPINE DOSE & RISK OF SEIZURES

(4) CLOZAPINE SIDE EFFECTS: GASTRO-INTESTINAL

Here is one of the clinically relevant slide from this discussion:

CLOZAPINE INDUCED GASTRO-INTESTINAL HYPOMOTILITY: MECHANISM

(5) CLOZAPINE SIDE EFFECTS: HYPERSALIVATION

INTERESTED IN ACCESS TO THIS & OTHER CLINICALLY RELEVANT LECTURE SERIES?

JOIN ACADEMY MEMBERSHIP:

This is a closed membership for medical professionals only.

400+ Clinically Relevant Chapters: Each chapter within these sections is of direct clinical relevance for your daily practice.
Journal Club: we will post the most recently published psychiatry articles relevant to your daily clinical practice.
Clinical Case Discussion: Dr. Singh (Psychiatry) and Dr. Kaur (Family Medicine) discuss clinical cases to integrate the clinical cases from Psychiatry and Medicine.
Discussion Forum & Community: Connect with other medical professionals and discuss your difficult-to-treat clinical cases.
Goal: is to have all important clinically relevant topics in one place for ease of access.

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$ 99/YR

DISCOUNTS AVAILABLE FOR: Residents & Students ONLY.

Email us your student information (program information and way to confirm your student status) to: HSingh@PsychiatryEducationForum.com