Urine Drug Tests: Benzodiazepines

LECTURE SERIES DAY 3: RELEASED TODAY

We continue our lecture series on the “Clinical Interpretation of Urine Drug Tests” with a discussion on the following topic:

URINE DRUG TESTS: BENZODIAZEPINES

Let’s begin by answering this question first:

Which of the following benzodiazepine will not be detected by most immunoassays unless hydrolysis with beta-glucuronidase is performed on the urine before testing?

Answer: (c) Lorazepam

To understand the rationale behind this answer, we should have a good understanding of benzodiazepines metabolism, which is important for the correct interpretation of urine drug tests for benzodiazepines.

Here is one of the slides from this chapter on the basics of Benzodiazepines Metabolism:

Read the complete list of upcoming lecture series schedule HERE

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