United Kingdom Parkinsons Disease Society Brain Bank Clinical Diagnostic Criteria’s


Diagnosis of a parkinsonian syndrome


  • Bradykinesia and at least one of the following:

  • Muscular rigidity.

  • Rest tremor (4-6 Hz).

  • Postural instability unrelated to primary visual, cerebellar, vestibular or proprioceptive dysfunction.



Supportive criteria for parkinson’s disease **(3 or more needed for diagnosis of definite parkinson’s disease)**


  • Unilateral onset

  • Excellent response to levodopa

  • Rest tremor present

  • Progressive disorder

  • Persistent asymmetry, affecting side of onset most

  • Severe levodopa-induced chorea

  • Levodopa response for five years or more

  • Clinical course of 10 years or more



Exclusion criterias


  • History of:

    * Cerebrovascular disease with stepwise progression

    * Repeated head injury

    * Antipsychotic or dopamine-depleting drugs

    * Definite encephalitis and/or oculogyric crises on no drug treatment

  • More than one affected relative

  • Sustained remission

  • Negative response to large doses of levodopa (if malabsorption excluded)

  • Strictly unilateral features after three years

  • Other neurological features: supranuclear gaze palsy, cerebellar signs, early severe autonomic involvement, Babinski sign, early severe dementia with disturbances of language, memory or praxis.

  • Exposure to known neurotoxin



Source: Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. JNeurol Neurosurg Psychiatry 1992; 55: 181-184. (pdf)

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Dr. Harvinder Singh, M.D. (Admin)

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