Therapeutic Drug Monitoring: ARIPIPRAZOLE

Therapeutic Drug Monitoring: Aripiprazole

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Therapeutic drug monitoring have limited value in the clinical use of aripiprazole. It may be useful in assuring adherence and optimizing response in individuals.

 

  • Target plasma level: range of between 150- 210 ng/mL is suggested.

  • Laboratory alert level = 1000 ng/ml.

  • Time to reach steady state = 14 days.

  • For Adverse Effects: No or only mild side effects were detected in patients with aripiprazole plasma concentrations between 110 and 249 ng/ml.

Coadministration of CYP3A4 inducer: resulted in approximately 60% lower mean Concentration:Dose (C:D) ratios of aripiprazole, dehydroaripiprazole, and the sum of aripiprazole and dehydroaripiprazole.

 

Combination with CYP2D6 inhibitor: resulted in a 45% higher mean C:D ratio of aripiprazole, with no effect on the C:D ratio of dehydroaripiprazole.

 

Combination with lithium: 43% higher mean C:D ratio of aripiprazole.

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  4. Ther Drug Monit. 2009 Apr;31(2):233-8.
  5. Ther Drug Monit. 1998 Aug;20(4):380-4.
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  8. Acta Pharm. 64 (2014) 387–401.
  9. Psychiatr. Pol. 2017; 51(6): 1059–1077.
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For Physician's Guide for Clinical Psychiatry Subscribers

Read this COURSE CHAPTER for detailed information on following topics:

  1. Therapeutic Drug Monitoring: Aripiprazole.
  2. Therapeutic Drug Monitoring: Risperidone.
  3. Therapeutic Drug Monitoring: Olanzapine.
  4. Therapeutic Drug Monitoring: Clozapine.
  5. Therapeutic Drug Monitoring: Quetiapine.
  6. Therapeutic Drug Monitoring: Ziprasidone.
  7. Recommendation Summary of Therapeutic Drug Monitoring for antipsychotics.

Dr. Harvinder Singh, MD

Admin, Psychiatry Education Forum

Physician's Guide for Clinical Psychiatry

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