Tasimelteon: Important Drug Interactions
Q.2. Tasimelteon is a melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder.
Addition of which of the following medication can result in potentially large decrease in Tasimelteon exposure with reduced efficacy?
Answer: (c) Modafinil
Avoid use of Tasimelteon in combination with CYP3A4 inducers because of a potentially large decrease in tasimelteon exposure with reduced efficacy:
- Modafinil is CYP3A4 inducers
- Cimetidine, Suboxone and Clarithromycin are CYP3A4 inhibitors.
Second important CYP450 enzyme is 1A2:
Avoid use of Tasimelteon in combination with strong CYP1A2 inhibitors because of a potentially large increase in tasimelteon exposure and greater risk of adverse reactions: ex: Fluvoxamine.
Source: Tasimelteon package insert.
Please do post your questions or comments below.
Dr. Harvinder Singh, M.D. (Admin)
Enroll in our online course to have access to all important clinically relevant psychiatry topics in one place.