Tardive Dyskinesia Management

Patient with history of schizoaffective disorder admitted for worsening of command auditory hallucinations and paranoid delusions. He needed higher doses of haloperidol for stabilization of psychotic symptoms, which resulted in development of tardive dyskinesias. How will you manage his psychotic symptoms and tardive dyskinesias?

The detailed answer is available in the following course chapter:

(NOTE: this chapter is available for free preview)

Antipsychotics: Tardive Dyskinesias Management.

This chapter will be summarized in the following 9 sections:

  1. Which medications are known to induce tardive dyskinesias after long term administration?

  2. Which medical conditions can present with symptoms similar to tardive dyskinesias, and hence needs to be ruled out first?

  3. How to clinically differentiate tardive dyskinesias from akathisia, parkinsonian tremors and acute dystonia?

  4. Will you consider antipsychotic discontinuation in patient with tardive dyskinesias?

  5. Switching to atypical antipsychotics are preferred, but which atypical antipsychotics will you choose?

  6. If medications discontinuation/taper is not an option. What other medications can help this patient?

  7. Will use of anticholinergic medications help with tardive dyskinesias?

  8. Role of ECT (electroconvulsive therapy) or Pallidal deep brain stimulation for tardive dyskinesias.

  9. Compare VMAT2 Inhibitors: Tetrabenazine, Valbenazine and Deutetrabenazine.

COMPARING VMAT2 INHIBITORS FOR TARDIVE DYSKINESIA:

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