Sertraline Receptor Profile

Which of the following statement is false regarding Sertraline?

 


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A is correct:
Sertraline is more potent at blocking DA receptor uptake than are other selective serotonin reuptake inhibitors (SSRIs) and TCAs.

 

Source:

  1. Hiemke and Härtter 2000. PubMed PMID: 10674711.
  2. Richelson 1994.

B is correct:
The antagonism of alpha 1-adrenoreceptors by sertraline is at least 10-fold more than that of other SSRIs, although this antagonism does not translate into clinically meaningful hypotension or reflex tachycardia.

 

Source:

  1. Hiemke and Härtter 2000. PubMed PMID: 10674711.

D is correct:
Peak plasma levels are somewhat lower in young males, compared with females and older males.

 

Source:

  1. Ronfeld et al. 1997.
  2. Warrington 1991.
  3. “Zoloft” 2001.

E is correct:
Patients with liver disease experience decreased sertraline metabolism. On the other hand, renal impairment does not appreciably influence the metabolism of sertraline.

 

Source:

  1. Hiemke and Härtter 2000. PubMed PMID: 10674711.

C is false:
Among the various SSRIs, Sertraline is second only to paroxetine in potency for 5-HT reuptake blockade.

 

Source:

  1. Hiemke and Härtter 2000. PubMed PMID: 10674711.
  2. Soc Biol Psychiatry 50:345–350, 2001. PubMed PMID: 11543737.

 


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