Q.11: Which of the following medication is NOT known to increase the apparent clearance of lamotrigine?(a) Carbamazepine(b) Estrogen-containing oral contraceptives(c) Rifampin(d) Valproate(e) Phenobarbital
Answer –>(d) Valproate
Lamotrigine is metabolized predominantly by glucuronic acid conjugation, so medications that induce or inhibit glucuronidation may affect the apparent clearance of lamotrigine.
Medications that can INCREASE the apparent clearance of lamotrigine:
- Estrogen-containing oral contraceptives
Medications that can DECREASE the apparent clearance of lamotrigine:
- Valproate (*)
Medications that will NOT AFFECT the apparent clearance of lamotrigine:
Also note that Lamotrigine have no effects on the pharmacokinetics of lithium.
Source: lamotrigine package insert.
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Dr. Harvinder Singh, M.D. (Admin)
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