Psychotropic Drug Interactions: Clozapine and GERD Medications.

A 32-year-old female with history of schizophrenia is admitted for a recent worsening of command auditory hallucinations and negative symptoms of schizophrenia. She was initiated on clozapine and gradually titrated to 250 mg bedtime dose with a good response.
The patient later reports worsening of GERD symptoms and was initiated on her home medication for GERD. This resulted in sudden deterioration and worsening of underlying psychotic symptoms. 

Which of the following GERD medication can result in a decrease in clozapine levels?

Detailed answer is available in our first email of Psychotropics Drug-Drug Interactions lecture series:-


(1) Medications affecting Clozapine levels (part-1)

  • Release Date: Jan 08, 2020.

(2) Medications affecting Clozapine levels (part-2)

  • Release Date: Jan 10, 2020.

(3) Medications affecting Clozapine levels (part-3)

  • Release Date: Jan 13, 2020.

(4) Interactions with Warfarin: (I) Antidepressants.

  • Release Date: Jan 15, 2020.

(5) Interactions with Warfarin: (II) Antipsychotics.

  • Release Date: Jan 17, 2020.

(6) Antidepressants and Cardiac Medications

  • Release Date: Jan 20, 2020.

(7) Lamotrigine and Oral Contraceptive Pills.

  • Release Date: Jan 22, 2020.

(8) Lamotrigine and Other Anticonvulsants (Carbamazepine, Phenytoin, Phenobarbital, Pyrimidine or Valproate).

  • Release Date: Jan 24, 2020.

(9) Tamoxifen and psychotropic medications.

  • Release Date: Jan 27, 2020.

(8) Medical Cannabis and Psychotropic Interactions. 

  • Release Date: Jan 29, 2020.

  • Course is frequently updated.
  • Each chapter includes references: with full pdf article or PubMed link for each article.
  • Total chapters= 235 and counting.
  • Triweekly Email Clinical Summary: Subscribers receive 3 emails/week containing chapters clinical summary (Mon, Wed, and Fri): including this above lecture series.
  • Goal is to have all important clinically relevant topics in one course: aimed at busy clinical professionals for quick review.

Dr. Harvinder Singh

Admin, Psychiatry Education Forum

Related Articles