How to use Pramipexole for Bipolar Depression?

Pramipexole is currently only FDA approved for Parkinson’s disease & Moderate-to-severe primary Restless Legs Syndrome but Pramipexole has promising data as an augmentation option for the management of treatment-resistant unipolar and bipolar depression. 

The serotonergic and noradrenergic hypotheses do not fully account for the neurobiology of depression or the mechanism of action of effective antidepressants. Research implicates a potential role of the dopaminergic system in the pathophysiology of bipolar disorder. (Biol Psychiatry. 2004 Jul 1;56(1):54-60)

Today we posted the following lecture in our Psychiatry Education Forum Academy: 

What is the likely mechanism of action behind Pramipexole’s efficacy in bipolar depression?

This chapter is summarized in the following clinically relevant topics:

  1. Mechanism of Action
  2. How to Dose & Titrate: Bipolar 1 vs Bipolar 2
  3. Drug Interactions: Antipsychotics D3 Affinity
  4. Monitor for Adverse Events
  5. How to Discontinue: Taper Schedule?

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  • 30+ Courses/Sections: Each chapter within these sections is of direct clinical relevance for your daily practice. 
  • Journal Club: we will post the most recently published psychiatry articles relevant to your daily clinical practice.
  • Coffee Club: contain short discussions with clinical experts in the field of psychiatry.
  • Essentials of Inpatient Psychiatry Book: All chapters from this book are included in the academy sections. 
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  • Goal: is to have all important clinically relevant topics in one place for ease of access.
 

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