Pharmacological Interventions for Benzodiazepine Discontinuation


 

Cochrane conducted this database of systematic reviews to assess the benefits and harms of pharmacological interventions to facilitate discontinuation of chronic benzodiazepine use.

 

(a) VALPROATE:

  • Potential benefit found for benzodiazepines discontinuation at end of intervention (Grade: very low‐quality evidence).

  • Potential benefit found for benzodiazepine relapse at end of intervention (Grade: 

    very low‐quality evidence).

  • No effect on benzodiazepine discontinuation at longest follow-up (Grade: very low‐quality evidence).

  • No effect on benzodiazepine relapse at longest follow-up (Grade: very low‐quality evidence).

  • No effect on symptoms of anxiety at end of intervention (Grade: very low‐quality evidence).

 


(b) TRICYCLIC ANTIDEPRESSANTS (IMIPRAMINE):

  • potential benefit found for tricyclic antidepressants at longest followup (Grade: low‐quality evidence).

  • potentially positive effects on benzodiazepine withdrawal symptoms at end of intervention (Grade: very low-quality evidence).

 


(C) PREGABALIN:

  • potentially positive effects on benzodiazepine withdrawal symptoms at end of intervention (Grade: very low-quality evidence).

  • Pregabalin did reduced symptoms of anxiety at end of intervention (Grade: very low-quality evidence).

 


(d) PAROXETINE:

  • potentially positive effects on benzodiazepine withdrawal symptoms at end of intervention (Grade: very low-quality evidence).

  • However positive effect of paroxetine on benzodiazepine withdrawal symptoms did not persist until longest follow‐up (Grade: very low-quality evidence).

  • Paroxetine did reduced symptoms of anxiety at end of intervention (Grade: very low-quality evidence).

 


SOURCE:
  1. Cochrane Database Syst Rev. 2018 Mar 15;3:CD011481.
  2. Cochrane Database Syst Rev. 2006 Jul 19;(3):CD005194.

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Dr. Harvinder Singh, M.D. (Admin)


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