PERSERIS™ (Risperidone): Once-Monthly Injectable.

FDA approved the first once monthly long acting injectable form of Risperidone: PERSERIS™ (in July 2018).



  • Schizophrenia in adults.


  • 90 mg and 120 mg. 

  • Establish tolerability with oral risperidone first.

  • Supplementation with oral risperidone is not recommended.

  • Do not administer more than one dose (90 mg or 120 mg total) per month.


  • Administered as an abdominal subcutaneous injection only.

  • Do not administer by any other route.

  • Failure to fully mix the medication could result in incorrect dosage.

  • Allow package to come to room temperature for at least 15 minutes prior to preparation.


  • PERSERIS 90 mg = 3 mg/day oral risperidone.

  • PERSERIS 120 mg = 4 mg/day oral risperidone.

  • Patients who are on stable oral risperidone doses < 3 mg/day or > 4 mg/day may not be candidates for PERSERIS.


  • INITIATE AT LOW DOSE OF 90 MG: for patient also taking strong CYP2D6 Inhibitors (fluoxetine or paroxetine).

  • INITIATE AT HIGH DOSE OF 120 MG: for patient also taking strong CYP3A4 Inducers (carbamazepine).


Please do post your questions or comments below. 

Dr. Harvinder Singh, M.D. (Admin)

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