Parkinson’s disease and Impulse Control Disorders

Impulse control disorders (ICDs) in Parkinson’s disease:

(a) Problem or Pathological Gambling

(b) Compulsive Buying

(c) Compulsive Sexual Behavior

(d) Binge or Compulsive Eating


Dopamine Agonist Treatment and Association with ICDs

This is the strongest and most consistent predictor of ICDs.

According to data obtained from DOMINION study:

  • ICDs in patient on dopamine agonist + levodopa = 17.7%.
  • ICDs in patient on dopamine agonist – levodopa = 14%.
  • ICDs in patient on levodopa – dopamine agonist = 7.2%.

(a) Among dopamine agonists: no statistically significant difference in overall ICD frequency between pramipexole and ropinirole.

(b) Strong class association between dopamine agonist use and all ICDs.

(c) also an association between levodopa use and ICDs.

(d) an association between higher levodopa dosages, but not dopamine agonist dosages, and ICDs.


185th chapter added to course today: (13.5) Parkinson’s disease and Impulse Control Disorders.

https://psychiatryeducationforum.teachable.com/courses/451404/lectures/8995044

Subscribers of Physician’s Guide for Clinical Psychiatry will have access to more details information on this topic, including following topics:

  1. How common are ICDs in Parkinson’s disease.
  2. Semi-structured Diagnostic Instruments (Scales).
  3. Demographic Risk Factors.
  4. Dopamine Agonist treatment and association with ICDs.
  5. Levodopa Equivalent Daily Dosages.
  6. Treatment of ICDs in Parkinson’s Disease.

Please do post your questions or comments below. 


Dr. Harvinder Singh, M.D. (Admin)


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