Underlying Mechanism Behind using Creatine:
- Creatine supplementation is known to increase –> cerebral concentration of phosphocreatine.
- Increase cerebral creatine –> causes shift in brain creatine kinase activity –> increase production of ATP from phosphocreatine.
- This increased generation of ATP –> known to contribute to earlier and increased response to antidepressants.
The following study done by Lyoo et al tested this hypothesis:
- n= 52 women with MDD
- Duration= 8-week double-blind placebo-controlled clinical trial
- Group 1= Escitalopram + creatine (5 g/day, N=25) or
- Group 2= Escitalopram + placebo (N=27).
- Dose of Escitalopram= 10 mg/day for the first week and then 20 mg/day for the following 7 weeks.
- Scale= Hamilton Depression Rating Scale (HAM-D) score.
Results of this study:
- RESPONSE: Women who received creatine augmentation showed greater improvement of depressive symptoms as early as week 2.
|Week 2||Week 4||Week 8|
|Creatine (N=25)||32.0% (N=8)||68.0% (N=17)||64.0% (N=16)|
|Placebo (N=27)||3.7% (N=1)||29.6% (N=8)||63.0% (N=17)|
- REMISSION (AT WEEK 8):
- ADVERSE EVENTS: Similar in both groups- tension headache, nausea and/or vomiting, and sleep difficulties. These are likely related to the use of SSRIs.
|Creatine||43.4% (36 events)|
|Placebo||46.4% (45 events)|
The present results suggest that creatine augmentation with the Escitalopram, provides a promising therapeutic approach for MDD in terms of its superior efficacy, relatively good tolerability, minimal side effects, and easy attainability.
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Dr. Harvinder Singh, M.D. (Admin)
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