Q: Optimal Duration of Augmentation Antipsychotic use in Bipolar Disorder?

Patient with diagnosis of bipolar I disorder had remission of his recent manic episode with combination of mood stabilizer (lithium/ divalproex) and antipsychotic (risperidone/ olanzapine) treatment.

Q: What is an optimal duration of antipsychotic use in this patient with bipolar disorder following remission of manic episode?

(a) 4 weeks (1 month)

(b) 12 weeks (3 months)

(c) 24 weeks (6 months)

(d) 48 weeks (1 year)

Answer: (c)


Continuing antipsychotics beyond 6 months may not further protect against mania recurrence and can causes more weight gain.

More detailed explanation is available in Physician’s Guide for Clinical Psychiatry course. Course subscribers can read more details on this topic here:


Dr. Harvinder Singh, M.D. (Admin)

Course Instructor (Physician’s Guide for Clinical Psychiatry)

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