NeuroAnatomical Location of Depression Symptoms

NeuroAnatomical Location of Depression Symptoms


  1. Amygdala and Prefrontal cortex: Guilt, Suicidality and Worthlessness.
  2. Nucleus accumbens: Pleasure, Interest, and Energy.
  3. Hypothalamus: Sleep and Appetite.
  4. Functional imaging studies associate depression with opposite patterns of activity in these areas: Hypoactivity in dlPFC (dorsolateral Prefrontal Cortex) but hyperactivity in vmPFC (ventromedialPrefrontal Cortex).
  • dlPFC lesions exacerbate depressive symptoms whereas vmPFC lesions diminish depressive symptoms.
  • Clinical Implication in Depression Treatment: TMS mediated excitation of dlPFC but DBS mediated inhibition of vmPFC.


Source: Behav Brain Res. 2009 Aug 12; 201(2): 239–243.

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Dr. Harvinder Singh, M.D. (Admin)

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