Modifiable Predictors of Conversion to Dementia in Mild Cognitive Impairment

Modifiable Predictors of Conversion to Dementia in Mild Cognitive Impairment (MCI)

  1. Diabetes: increases the risk of Alzheimer’s dementia in people with amnestic MCI and that it increases the risk of any-cause dementia in people with any-type or nonamnestic MCI (Grade 2 evidence).

  2. Hypertension: does not predict conversion from any-type MCI to all-cause dementia (Grade 2 evidence).

  3. Hypercholesterolemia: is not associated with risk of conversion from any-type MCI to all-cause dementia (Grade 2 evidence).

  4. Smoking: is not associated with risk of conversion from amnestic MCI to Alzheimer’s dementia or any-type MCI to all-cause dementia (Grade 1 evidence).

  5. Heavy Alcohol Use: predicts conversion from any-type MCI to dementia (Grade 2 evidence).

  6. More Depressive Symptoms: predict conversion from any-type MCI to all-cause dementia from epidemiological studies (Grade 1 evidence).

  7. Presence of Neuropsychiatric Symptoms in people with any type MCI predicts conversion to all-cause dementia (Grade 2 evidence).

  8. Anxiety Symptoms: inconsistent evidence in association with conversion from amnestic MCI to Alzheimer’s dementia.

  9. Apathy: inconsistent evidence in association with risk of conversion from amnestic MCI to Alzheimer’s dementia or from any-type MCI to dementia.

  10. Mediterranean Diet: associated with decreases risk of conversion from amnestic MCI to Alzheimer’s dementia (Grade 2 evidence).

  11. Lower Folate Serum level: predicts conversion from any-type MCI to all-cause dementia (Grade 2 evidence).

  12. Homocysteine Serum level: inconsistent evidence.

  13. Amount of Education: does not predict conversion from any-type MCI to all-cause dementia or from amnestic MCI to Alzheimer’s dementia (Grade 1 evidence).

Source: Am J Psychiatry 172:4, April 2015.


 

Please do post your questions or comments below. 


Dr. Harvinder Singh, M.D. (Admin)


Enroll in our online course to have access to all important clinically relevant psychiatry topics in one place.


Related Articles