Severe Melancholic Depression: How to Manage?
Melancholic features in major depressive disorder are characterized by:
ONE of the following present during the most severe period of the current episode:
- Loss of pleasure in all, or almost all, activities.
- Lack of reactivity to usually pleasurable activities.
THREE (or more) of the following:
- Profound despondency, despair, and/or moroseness or by so-called empty mood.
- Depression worse in morning
- Early morning awakening (at-least 2-hour before awakening)
- Marked psychomotor agitation or retardation.
- Significant weight loss or anorexia
- Excessive or inappropriate guilt.
It is important to have knowledge of how to manage this major depressive disorder with melancholic features.
Let’s Begin by Answering this Question First
Answer: Venlafaxine
Here is the summary slide from our journal club discussion on this topic of managing unipolar non-psychotic depression:
FOR ACADEMY MEMBERS:
The Psychopharmacology Algorithm Project at the Harvard South Shore Program: An Update on Unipolar Nonpsychotic Depression.
This 45 minutes journal club video discussion will answer the following 11 clinically relevant questions:
- Which medications are first-line treatment options in the management of MDD [in outpatient setting]?
- What are the next step options after the first-line treatment fails (poor or no response): Augmentation options?
- What are the next step options after the first-line treatment fails (poor or no response): Switching options?
- Management options for Treatment-Resistant Depression without comorbidities.
- Management options for Treatment-Resistant Depression with and without Atypical Features.
- Management options for Treatment-Resistant Depression with Medical Comorbidities.
- Management options for Treatment-Resistant Depression with Chronic Pain.
- Management options for Treatment-Resistant Depression with OCD.
- Management options for Treatment-Resistant Depression with ADHD.
- Management options for Treatment-Resistant Depression with PTSD.
- How to manage Severe Melancholic Depression [in Inpatient Settings]?
academy
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