Mechanism of Action of Medications Approved for Weight Loss

Mechanism of Action of

Medications Approved for Weight Loss

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(1) Lorcaserin

 

Stimulates 5HT2C receptor —> stimulates POMC neuron —-> releases alpha MSH —> acts on MC4R —> resulting in suppression of appetite

  • POMC = Pro-OpioMelanoCortin Neuron
  • MSH =  Melanocyte Stimulating Hormone
  • MC4R = Melanocortin-4 Receptor

 

(2) Phentermine

 

Increases NE and Dopamine at POMC neuron —-> releases alpha MSH —> acts on MC4R —> resulting in suppression of appetite

 

(3) Topiramate

 

Increases GABA and decreases Glutamate on AgRP/NPY neuron —> decreases release of AgRP/NPY —> no longer stimulation of appetite —> decreased appetite

  • AgRP/NPY neuron = Agouti-Related Protein/Neuropeptide Y Neuron

 

(4) Phentermine + Topiramate 

 

Additive effects as above

 

(5) Bupropion

 

Increases NE and Dopamine at POMC neuron —-> releases alpha MSH —> acts on MC4R —> resulting in suppression of appetite

 

(6) Bupropion + Naltrexone (Contrave)

 

Naltrexone inhibits the auto-inhibition of POMC pathway –> promotes above mentioned Bupropion action –> suppression of appetite.

Please do post your questions or comments below. 


Dr. Harvinder Singh, M.D. (Admin)


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