Lamotrigine Clearance: Drug Interactions

Which of the following medication is NOT known to INCREASE the apparent clearance of lamotrigine?

Choose your answer before scrolling down. 



Lamotrigine is metabolized predominantly by glucuronic acid conjugation, so medications that induce or inhibit glucuronidation may affect the apparent clearance of lamotrigine.

We have summarized this interaction in the following table:


so the answer to above question is Valproate.

Also note that Lamotrigine have no effects on the pharmacokinetics of lithium.

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