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Lamotrigine is metabolized predominantly by glucuronic acid conjugation, so medications that induce or inhibit glucuronidation may affect the apparent clearance of lamotrigine.
We have summarized this interaction in the following table:
so the answer to above question is Valproate.
Also note that Lamotrigine have no effects on the pharmacokinetics of lithium.
For Physician's Guide for Clinical Psychiatry Subscribers:
Course subscribers will have access to the following two chapters with more detailed information:
Dr. Harvinder Singh, MD
Admin, Psychiatry Education Forum.