Journal Club #2: Antipsychotics Duration and Weight Gain Risk

This is our Second Psychiatry Education Forum’s Journal Club.

In this journal club, we will answer the following six clinically relevant questions:

(1) Do ALL ANTIPSYCHOTICS result in mean increase in body weight with increased DURATION OF USE?

(2) Which ANTIPSYCHOTIC and time period (DURATION) have more significant increase in weight gain?

(3) Which antipsychotics showed NO statistically significant weight change post baseline?

(4) Will switching to WEIGHT NEUTRAL ANTIPSYCHOTICS result in weight loss?

(5) How is weight gain in ANTIPSYCHOTIC NAIVE patients?

(6) Which factors are important to consider with weight gain from antipsychotics?

Article: Bak M, Fransen A, Janssen J, van Os J, Drukker M. Almost all antipsychotics result in weight gain: a meta-analysis. PLoS One. 2014 Apr 24;9(4):e94112. PubMed PMID: 24763306 (pdf)

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