Journal Club #3: Bipolar Depression Guidelines: CANMAT & ISBD Versus Psychopharmacology Algorithm Project

Today we posted the following third journal club in PEFA Journal Club’s discussion series:

Journal Club #3:

The Psychopharmacology Algorithm Project at the Harvard South Shore Program: An Update on Bipolar Depression.

Article: Harv Rev Psychiatry. 2010 Jan-Feb;18(1):36-55. PubMed PMID: 20047460

This journal club will compare the following two guidelines for bipolar depression management:

  1. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines.
  2. Psychopharmacology Algorithm Project at the Harvard South Shore Program: An Update on Bipolar Depression (2019)

These guidelines will be compared in terms of First, Second, and Third-line treatment. This journal club will answer the following 10 clinically relevant questions:

  1. Which medications are not recommended treatment for bipolar depression?
  2. Which Non-FDA approved medication is the first-line treatment per both guidelines?
  3. Which FDA approved treatment is not recommended by Harvard South Shore program update?
  4. “Adjunctive” use of which medication is considered first-line treatment per CANMAT & ISBD guidelines?
  5. Which one medication moved from second-line treatment (in CANMAT & ISBD) to first-line treatment (in Harvard South Shore program update)?
  6. “Monotherapy” with which medication is considered third-line treatment per CANMAT & ISBD guideline?
  7. Which medication(s) was recommended by CANMAT but NOT recommended by Harvard South Shore program update due to safety concerns?
  8. Which antidepressant is preferred as an adjunctive treatment, over other antidepressants?
  9. Does aripiprazole have efficacy as monotherapy or as an adjunct or no efficacy for bipolar depression?
  10. Which non-medication option was recommended by both guidelines?


Psychiatry Education Forum’s Journal Club is an additional feature for PEF Academy’s members. All academy members will be automatically enrolled in this journal club.

Here we post the most recently published psychiatry articles relevant to your daily clinical practice with CME credits available for selective journal club activities. 


4.75 AMA PRA Category 1 Credits Available from June 26, 2021

→ CME Credits will increase with our upcoming journal club video discussions.

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of PeerPoint Medical Education Institute, LLC and Psychiatry Education Forum LLC. The PeerPoint Medical Education Institute, LLC is accredited by the ACCME to provide continuing medical education for physicians.

The PeerPoint Medical Education Institute, LLC designates this enduring activity for a maximum of 4.75 AMA PRA Category 1 Credit(s)TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Accreditation & Designation Statements and Disclosure Report:



This is a closed membership for medical professionals only.

  • 30+ Courses/Sections: Each chapter within these sections is of direct clinical relevance for your daily practice. 
  • Journal Club: we will post the most recently published psychiatry articles relevant to your daily clinical practice.
  • Coffee Club: contain short discussions with clinical experts in the field of psychiatry.
  • Essentials of Inpatient Psychiatry Book: All chapters from this book are included in the academy sections. 
  • Discussion Forum & Community: Connect with other medical professionals and discuss your difficult-to-treat clinical cases.
  • Conference Discounts: Academy members get discounted access at our conferences. 
  • Goal: is to have all important clinically relevant topics in one place for ease of access.


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