[Journal Club #12 + Coffee Club]: Is Ketamine Safe with History of Psychosis?

Today we posted the following 12th journal club in PEFA Journal Club’s discussion series and discussion with an expert in our Coffee Club’s discussion section:

Journal Club #12:

Is Ketamine Safe with History of Psychosis & Implications for Its Therapeutic Use.

Article: JAMA Network Open. 2020 May; 3(5): e204693.


This journal club will answer the following seven clinically relevant questions:

  1. Can a single dose of ketamine induce acute psychotic episodes when given to those who never had psychosis?
  2. Risk of psychosis in patients with a history of schizophrenia.
  3. Does ketamine affect both positive and negative symptoms of schizophrenia?
  4. Role of bolus before continuous infusion of ketamine in producing psychotic symptoms and do this differ for positive versus negative symptoms? 
  5. Do psychosis risk differs between intravenous and non-intravenous mode of ketamine delivery?
  6. Timeline for onset and duration of psychosis after ketamine administration.
  7. Role of observer-rated scales for psychosis (BPRS/PANSS) in schizophrenia versus psychosis induced by hallucinogens/psychotomimetics.

Note: CME Credits not available for this educational activity.

In this Coffee Club Dr. Asim Shah will answer the following clinical questions:

  1. Should this risk of psychosis stop us from considering ketamine in our practice?
  2. Who is an ideal patient to go for ketamine/esketamine therapy?
  3. Is there a subgroup of depressed patients that may respond better to ketamine?
  4. What is the balanced course of the length of treatment with ketamine?
  5. Is it possible to predict non-responders early on, so we can avoid long exposure?
  6. Advice for practitioners who are still skeptical about the use of ketamine.


Psychiatry Education Forum’s Journal Club is an additional feature for PEF Academy’s members. All academy members will be automatically enrolled in this journal club.

Here we post the most recently published psychiatry articles relevant to your daily clinical practice with CME credits available for selective journal club activities. 


4.75 AMA PRA Category 1 Credits Available from June 26, 2021

→ Note that the above journal club discussion is not included for CME credits.

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of PeerPoint Medical Education Institute, LLC and Psychiatry Education Forum LLC. The PeerPoint Medical Education Institute, LLC is accredited by the ACCME to provide continuing medical education for physicians.

The PeerPoint Medical Education Institute, LLC designates this enduring activity for a maximum of 4.75 AMA PRA Category 1 Credit(s)TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Accreditation & Designation Statements and Disclosure Report:



This is a closed membership for medical professionals only.

  • 30+ Courses/Sections: Each chapter within these sections is of direct clinical relevance for your daily practice. 
  • Journal Club: we will post the most recently published psychiatry articles relevant to your daily clinical practice.
  • Coffee Club: contain short discussions with clinical experts in the field of psychiatry.
  • Essentials of Inpatient Psychiatry Book: All chapters from this book are included in the academy sections. 
  • Discussion Forum & Community: Connect with other medical professionals and discuss your difficult-to-treat clinical cases.
  • Conference Discounts: Academy members get discounted access at our conferences. 
  • Goal: is to have all important clinically relevant topics in one place for ease of access.


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