Inflammatory Biomarkers and Risk of Schizophrenia

Inflammatory Biomarkers and Risk of Schizophrenia

 

Question: Whether inflammatory biomarkers have an effect on the risk of developing schizophrenia.?

Findings:

This study published in JAMA Psychiatry (Published online November 1, 2017) answered this questions using the 2-sample mendelian randomization study.

  • Overall they did not find strong evidence that lifelong exposure to increased action of these pro-inflammatory cytokines increases schizophrenia risk, as previously hypothesized.
  • Blockade of IL-6 effects and low CRP levels might instead increase schizophrenia risk.
  • 2-fold increments in circulating levels of CRP and soluble interleukin-1 receptor levels were associated with a 10% reduction and a 6% increase in the lifetime odds of developing schizophrenia.

Meaning:

  • They found that blockade of interleukin-6 effects and low C-reactive protein levels might increase schizophrenia risk, possibly due to increased susceptibility to early life infection.

Source: JAMA Psychiatry. doi:10.1001/jamapsychiatry.2017.3191

 

Please do post your questions or comments below. 


Dr. Harvinder Singh, M.D. (Admin)


Enroll in our online course to have access to all important clinically relevant psychiatry topics in one place.


Related Articles