Inflammatory Biomarkers and Risk of Schizophrenia

Inflammatory Biomarkers and Risk of Schizophrenia


Question: Whether inflammatory biomarkers have an effect on the risk of developing schizophrenia.?


This study published in JAMA Psychiatry (Published online November 1, 2017) answered this questions using the 2-sample mendelian randomization study.

  • Overall they did not find strong evidence that lifelong exposure to increased action of these pro-inflammatory cytokines increases schizophrenia risk, as previously hypothesized.
  • Blockade of IL-6 effects and low CRP levels might instead increase schizophrenia risk.
  • 2-fold increments in circulating levels of CRP and soluble interleukin-1 receptor levels were associated with a 10% reduction and a 6% increase in the lifetime odds of developing schizophrenia.


  • They found that blockade of interleukin-6 effects and low C-reactive protein levels might increase schizophrenia risk, possibly due to increased susceptibility to early life infection.

Source: JAMA Psychiatry. doi:10.1001/jamapsychiatry.2017.3191


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Dr. Harvinder Singh, M.D. (Admin)

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