Hypothyroidism and Depression: Clinical Facts

Hypothyroidism and Depression: Clinical Facts

1. Depressive patients have a higher frequency of hypothyroidism and patients with hypothyroidism have a higher occurrence of depressive syndrome.

2. Thyroid peroxidase antibodies have been positively associated with trait markers of depression.

3. T3 administration is the therapy of choice in patients with resistance to antidepressants.

4. Thyroxine treatment in patients older than 65 years does not improve cognition.

5. Genetic variants of thyroid hormone transporters or of deiodinases I and II may predispose to depression and, therefore, a personalized approach should be implemented.

6. Women show better improvement in depression scores with levothyroxine compared to men.

7. Studies have shown that suboptimal thyroid function increases vulnerability to the occurrence of depressive symptom and represents a modifiable risk factor for depression in females.

8. Note that brain-derived neurotrophic factor (BDNF) decreases during depressed states and normalize after treatment. Higher TSH is associated with lower baseline and reduced the increase of serum BDNF levels during antidepressant treatment in patients with MDD.

9. Levothyroxine taken at bedtime can significantly improved thyroid hormone levels. 


  1.  2013 Dec;38(4):365-77.
  2.  2014 Dec;169:112-7.
  3.  2010 Dec 13;170(22):1996-2003.
  4.  2015 Aug;58:114-9.


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Dr. Harvinder Singh, M.D. (Admin)

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