Hyperprolactinemia during Antipsychotics Treatment Increases the Coagulation Markers.

Hyperprolactinemia during Antipsychotics Treatment Increases the Coagulation Markers.


Participants: 182 patients with schizophrenia (male =89, female =93) who received antipsychotic treatments for at least 3 months.


  • Markers of venous thromboembolism (VTE): D-dimer, fibrin/fibrinogen degradation products, and thrombin–antithrombin (TAT) complex measured.
  • Serum prolactin concentrations measured.


  • Prolactin levels were significantly correlated with the logarithmic transformation of the D-dimer (r=0.320, P=0.002) and fibrin/fibrinogen degradation product levels (r=0.236, P=0.026) BUT
  • Not of the thrombin–antithrombin complex level (r=0.117, ns) among men.
  • However, no correlations were found between the VTE markers and prolactin levels among women.


  • Prolactin alone does not influence the process of platelets aggregation; rather, the combination of prolactin and adrenalin does.
  • Men with higher levels of prolactin had enhanced markers of activated coagulation (log D-dimer and log FDP) but that women did not show this tendency: Author hypothesize that differences in illness duration might have influenced this result.
  • Levels of D-dimer and FDP (but not TAT) were positively associated with prolactin levels in men: Author hypothesize that the plasma TAT levels of this study might have been increased by difficult sampling. Note that difficult sampling methods did not influence plasma D-dimer levels.


  • No control group.
  • Direct influence that each psychiatric disease has on the markers of activated coagulation remains unknown.
  • Did not investigate VTE itself using a multislice computed tomography scanner.
  • Risk factors such as family history and thrombophilia were not recorded.

Source: Neuropsychiatr Dis Treat. 2015; 11: 477–484.

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