Hyperprolactinemia during Antipsychotics Treatment Increases the Coagulation Markers.

Hyperprolactinemia during Antipsychotics Treatment Increases the Coagulation Markers.

 

Participants: 182 patients with schizophrenia (male =89, female =93) who received antipsychotic treatments for at least 3 months.

Method:

  • Markers of venous thromboembolism (VTE): D-dimer, fibrin/fibrinogen degradation products, and thrombin–antithrombin (TAT) complex measured.
  • Serum prolactin concentrations measured.

Results:

  • Prolactin levels were significantly correlated with the logarithmic transformation of the D-dimer (r=0.320, P=0.002) and fibrin/fibrinogen degradation product levels (r=0.236, P=0.026) BUT
  • Not of the thrombin–antithrombin complex level (r=0.117, ns) among men.
  • However, no correlations were found between the VTE markers and prolactin levels among women.

Discussion:

  • Prolactin alone does not influence the process of platelets aggregation; rather, the combination of prolactin and adrenalin does.
  • Men with higher levels of prolactin had enhanced markers of activated coagulation (log D-dimer and log FDP) but that women did not show this tendency: Author hypothesize that differences in illness duration might have influenced this result.
  • Levels of D-dimer and FDP (but not TAT) were positively associated with prolactin levels in men: Author hypothesize that the plasma TAT levels of this study might have been increased by difficult sampling. Note that difficult sampling methods did not influence plasma D-dimer levels.

Limitations:

  • No control group.
  • Direct influence that each psychiatric disease has on the markers of activated coagulation remains unknown.
  • Did not investigate VTE itself using a multislice computed tomography scanner.
  • Risk factors such as family history and thrombophilia were not recorded.

Source: Neuropsychiatr Dis Treat. 2015; 11: 477–484.

Please do post your questions or comments below. 


Dr. Harvinder Singh, M.D. (Admin)


Enroll in our online course to have access to all important clinically relevant psychiatry topics in one place.


Related Articles