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Antipsychotics that Increases Prolactin (45 to >100 ng/ml) and
Should be AVOIDED in Patients with Breast Cancer:
Antipsychotics that Increases Prolactin (20-50 ng/ml) and
Should be CAUTIONED in Patients with Breast Cancer:
Antipsychotics that Increases Minimal Prolactin and
Are PREFERRED in Patients with Breast Cancer:
Antipsychotic that may Lower Prolactin and
is PREFERRED in Patients with Breast Cancer:
For Typical Antipsychotics:
Phenothiazines (Chlorpromazine, Fluphenazine, Pipotiazine Trifluoperazine) and Butyrophenones (Haloperidol):
- 2-3 fold increase occurs within hours of treatment initiation with further 2 fold elevation in the following weeks.
Thioxanthenes (Flupentixol, Zuclopenthixol):
- Increase of prolactin 2-3 fold during the 1st month with reduction and normalisation after 6 months.
- Am J Psychiatry 2014;171:616-621.
- Journal of Psychopharmacology 22(2) Supplement (2008) 28–37
- The South London and Maudsley & Oxleas NHS Foundation Trusts Prescribing Guidelines, 11th edition. Wiley-Blackwell. 2012.
- Bazire S. Psychotropic Drug Directory. The Professionals’ Pocket Hand.
- Therapeutics and Clinical Risk Management 2007:3(5) 929–951.
Post by Dr. Harvinder Singh, M.D.
Our Most Recent Book Publication:
Essentials of Inpatient Psychiatry