Hydroxychloroquine & Psychotropics Interaction
Hydroxychloroquine is a medication used for the treatment of malaria, rheumatoid arthritis, and lupus erythematosus. In 2020, it gained attention as a potential treatment for COVID-19.
Hydroxychloroquine can interact with some psychiatric medications, including antidepressants and antipsychotics. The specific interactions can vary based on the particular medications involved. For this reason, it is clinically relevant to have the knowledge of this interaction when your patient is on Hydroxychloroquine.
We continue our academy’s clinical case discussion series with the following second case:
This patient continued to report the persistence of depression, anxiety, and OCD symptoms.
How will you manage this case?
Let’s answer this question first:
Answer: Escitalopram
- for the risk of QTc prolongation with a combination of escitalopram & hydroxychloroquine.
We have discussed this topic in our academy’s second clinical case discussion series:
- Academy’s Clinical Case Discussion Series is a feature for our academy members, where we discuss cases with the goal of improving your daily clinical practice.
Drug Interactions: Hydroxychloroquine & Psychotropics
This chapter will be summarized in the following sections:
- Clinical case discussion: patient on hydroxychloroquine with antidepressant & antipsychotic.
- Hydroxychloroquine: Metabolism & role of CYP450.
- Antidepressants & Hydroxychloroquine: (a) Preferred; (b) Cautions; (c) Avoid
- Antipsychotics & Hydroxychloroquine: (a) Preferred; (b) Cautions; (c) Avoid
Clinical Case Discussion #2
Drug Interaction: Hydroxychloroquine & Psychotrpics
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