Hippocampal Formation changes in Schizophrenia

Hippocampal Formation changes in Schizophrenia.

 

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Reduced glutamatergic transmission in the dentate gyrus is the basis for “reduced pattern separation” function in schizophrenia and, furthermore, serves to generate an “increase in long-term potentiation” in CA3 and “greater pattern completion” function, including the production of psychotic thoughts and the encoding of the psychotic productions as normal memory. i.e., during a novel experience, the schizophrenic hippocampus may erroneously retrieve a memory of a past event rather than appropriately encode a new distinct memory representation.

Source: Am J Psychiatry 167:10, October 2010

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