Hippocampal Formation changes in Schizophrenia

Hippocampal Formation changes in Schizophrenia.




Reduced glutamatergic transmission in the dentate gyrus is the basis for “reduced pattern separation” function in schizophrenia and, furthermore, serves to generate an “increase in long-term potentiation” in CA3 and “greater pattern completion” function, including the production of psychotic thoughts and the encoding of the psychotic productions as normal memory. i.e., during a novel experience, the schizophrenic hippocampus may erroneously retrieve a memory of a past event rather than appropriately encode a new distinct memory representation.

Source: Am J Psychiatry 167:10, October 2010

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