Ginkgo Biloba for Antidepressants Induced Sexual Dysfunction

Can Ginkgo Biloba help with antidepressants induced sexual dysfunction?

MECHANISM OF ACTION:

  • Prostaglandin synthesis and vasodilation ==>
  • resulting in increase peripheral blood flow and to facilitate the relaxation of smooth muscle tissue.

Ginkgo biloba extract has shown to improve the cognitive function in patients with vascular dementia. Note that Ginkgo biloba is widely used in China for this purpose due to its antioxidative and protective effects on neuronal cells.

WHAT DOSE IS FOUND EFFECTIVE?

According to an open-label trial published in 1998 (1):

  • dose ranged from 60 mg once daily to 120 mg twice daily (average = 209mg/d) 

CLINICAL FACTS:

  • Ginkgo biloba had a positive effect on all 4 phases of the sexual response cycle: desire, excitement (erection and lubrication), orgasm, and resolution (afterglow).
  • Women (91%) were more responsive to the sexually enhancing effects of ginkgo biloba than men (76%).

COMMON SIDE EFFECTS:

  • Gastrointestinal disturbances
  • Headache
  • Central nervous system activation.

DRUG INTERACTIONS:

  • Bleeding risk when combined with warfarin or aspirin.
  • Increased blood pressure risk when combined with a thiazide diuretic.
  • Ginkgo biloba can decrease the plasma concentrations of omeprazole, ritonavir and tolbutamide.

AVAILABLE PRODUCTS & COST:

 
(1) GNC Herbal Plus Ginkgo Biloba 120 mg:
  • 120 mg #100 capsules for $14 (amazon)
 
(2) Flora Ginkgo Biloba: 60 mg:
  • 60mg #60 capsules for $14 (eskinstore)
 

(3) Life Extension Ginkgo Biloba:

  • 120 mg #365 capsules for $30 (amazon)
 
(4) Nature’s Bounty Ginkgo Biloba:
  • 60 mg #200 Capsules for $8 (amazon)
 
(5) Nature’s Way Ginkgold:
  • 120 mg, #60 tablets for $20 (amazon)
 
(6) Pure Encapsulations:
  • 160 mg #120 tabs for $62 (amazon)
 
(7) The Vitamin Shoppe GB Extract:
  • 120 mg #120 tabs for $19 (vitaminshoppe)
 
NOTE:
  • The price was last checked on on Oct 4, 2020.
  • This is not a sponsored post and I will not get money if you buy or recommend them.

PLEASE SHARE YOUR PREFERRED BRANDS

(by using the reply option below)

INTERESTED IN LEARNING MORE?
JOIN OUR COURSE & GET ACCESS TO COMPLETE LECTURE SERIES:

Physician’s Guide for Clinical Psychiatry’s “PSYCHOTROPICS INDUCED SEXUAL DYSFUNCTION” lecture series will discuss the psychotropics sexual side effects in the following six chapters:

(1) WHAT QUESTIONS TO ASK?

  • This chapter will summarize the important questions you should ask each patient prior to the initiation and during treatment with psychotropic medications.
  • Questionnaire PDF available for download.

(2) ANTIDEPRESSANTS: WHICH ONE IS PREFERRED?

Antidepressant’s risk of sexual side effect will be classified into: 

  • High Risk
  • Medium Risk
  • Low Risk

(3) ANTIDEPRESSANTS: RISK WITH SSRIs?

  • Which SSRI carries less risk of sexual dysfunction?
  • Do SSRIs differ with type of sexual side effects?
  • Which patient population benefit from SSRIs sexual side effects?
  • Do sexual side effects improve with continuation of antidepressant treatment?
  • Do SSRIs sexual side effects differ between male & females?

(4) ANTIDEPRESSANTS: SEXUAL SIDE EFFECTS MANAGEMENT.

  • This chapter will discuss the 6 treatment approaches. 

(5) ANTIPSYCHOTICS: WHICH ONE IS PREFERRED?

  • Mechanism behind antipsychotics induced sexual dysfunction.
  • High risk antipsychotics
  • Low/No risk antipsychotics.

(6) ANTIPSYCHOTICS: SEXUAL SIDE EFFECTS MANAGEMENT.

  • This chapter will discuss the treatment approaches, including seven (7) augmentation approaches.

SUBSCRIBE TO:

PHYSICIAN’S GUIDE FOR CLINICAL PSYCHIATRY COURSE

  • Total chapters: 260+ Chapters.
  • Chapters and Sections are frequently updated.
  • Peer2Peer ChatRoom: Makes learning process more active via engagement among subscribers.
  • Journal Club: we will post most recently published psychiatry articles relevant to your daily clinical practice.
  • Coffee Club: contain short discussions with clinical experts in the field of psychiatry
  • Goal: is to have all important clinically relevant topics in one course.
  • Annual Subscription of $65/year: for continued access to course on an annual basis.

REFERENCES:

  1. Cohen AJ, Bartlik B. Ginkgo biloba for antidepressant-induced sexual dysfunction. J Sex Marital Ther. 1998 Apr-Jun;24(2):139-43. PMID: 9611693.
  2. Rapp M, Burkart M, Kohlmann T, Bohlken J. Similar treatment outcomes with Ginkgo biloba extract EGb 761 and donepezil in Alzheimer’s dementia in very old age: A retrospective observational study. Int J Clin Pharmacol Ther. 2018 Mar;56(3):130-133. PMID: 29319499; PMCID: PMC5822177. 
  3. Bridi R, Crossetti FP, Steffen VM, Henriques AT. The antioxidant activity of standardized extract of Ginkgo biloba (EGb 761) in rats. Phytother Res. 2001 Aug;15(5):449-51.
  4. Wang M, Peng H, Peng Z, Huang K, Li T, Li L, Wu X, Shi H. Efficacy and safety of ginkgo preparation in patients with vascular dementia: A protocol for systematic review and meta-analysis. Medicine (Baltimore). 2020 Sep 11;99(37):e22209.   
  5. Savaskan E, Mueller H, Hoerr R, von Gunten A, Gauthier S. Treatment effects of Ginkgo biloba extract EGb 761® on the spectrum of behavioral and psychological symptoms of dementia: meta-analysis of randomized controlled trials. Int Psychogeriatr. 2018 Mar;30(3):285-293. 

Related Articles