AdministratorJune 6, 2021 at 10:29 am
Thanks @Gary Graham for your insight. You are correct and I was not aware of this as a common side effect with antidepressants.
This cross-sectional study published in 2006 answered this question: J Clin Psychiatry. 2006 Nov;67(11):1754-9. (PMID: 17196056):
Inclusion Criteria for this study:
- 18+ years of age
- Responders to antidepressant therapy following at least 3 months of treatment.
- MDD in partial or full remission
Study participants were administered:
- Harvard Department of Psychiatry/National Depression Screening Day (HANDS) scale
- Epworth Sleepiness Scale
- Brief Fatigue Inventory
- Massachusetts General Hospital Cognitive and Physical Functioning Questionnaire (CPFQ)
- Study-specific questionnaire inquiring about the emergence of specific side effects such as apathy, fatigue, and inattentiveness.
Following Cognitive symptoms were reported by >30% of the responders on antidepressants (on CPFQ & study-specific questionnaire):
- Word-finding difficulty, and
- Mental slowing)
Also, they found a significant, positive relationship between the CPFQ and the severity of residual depressive symptoms as measured by the HANDS total score (F = 15.3, p = .0002).
- these symptoms are both side effects of the antidepressants as well as residual symptoms of MDD.